Delving into the Latest Updates on TP-2758 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

S2-7-5-A, TP-038, TP-120

+ [11]

Target-

Mechanism

Protein biosynthesis inhibitors

Therapeutic Areas

Infectious Diseases

Active Indication-

Inactive Indication

Bacterial Infections

Originator Organization

Tetraphase Pharmaceuticals (Bermuda) Ltd.

Active Organization-

Inactive Organization

Tetraphase Pharmaceuticals, Inc.

Drug Highest PhasePendingPhase 1

First Approval Date-

Regulation-

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A convergent total synthesis platform led to the discovery of TP-2758 from a series of novel 7-methoxy-8-heterocyclyl tetracycline analogs. TP-2758 demonstrated high in vitro potency against key Gram-negative pathogens including extended spectrum β-lactamases- and carbapenemase-producing Enterobacteriaceae and Acinetobacter spp. strains. This compound was efficacious when administered either intravenously or orally in multiple murine infection models and displayed a favorable preclinical pharmacological profile supporting its advancement into clinical development.

01 Nov 2009·IDrugs : the investigational drugs journal

Interscience Conference on Antimicrobial Agents and Chemotherapy--49th annual meeting. Part 2. 12-15 September 2009, San Francisco, CA, USA.

Article

Author: Murch, Lisa ; Turner, Ben

The Interscience Conference on Antimicrobial Agents and Chemotherapy held in San Francisco included topics covering new therapeutic developments for the treatment of infectious diseases. This conference report highlights selected presentations on several antibiotics in development including a broad-spectrum penem beta-lactam antibiotic, a novel siderophore monobactam, as well as other novel antibiotics. Investigational drugs discussed include sulopenem and sulopenem etzadroxil (both Pfizer Inc), BAL-30072 (Basilea Pharmaceutica International Ltd), TP-120 and TP-787 (both Tetraphase Pharmaceuticals Inc), NAI-107 (New Anti Infectives Consortium/NexThera Biosciences) and ABI-200 (AdRem Biotech/US Department of Agriculture).

100 Deals associated with TP-2758

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