Last update 30 May 2025

Hydrochlorothiazide/Metoprolol Tartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lopressor HCT
Target
NCC x β1-adrenergic receptor
Action
inhibitors, antagonists
Mechanism
NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors), β1-adrenergic receptor antagonists(Beta-1 adrenergic receptor antagonists)
Therapeutic Areas
Cardiovascular Diseases
Active Indication
Hypertension
Inactive Indication-
Originator Organization
Novartis Pharma AG
Active Organization
Validus Pharmaceuticals LLCValidus Pharmaceuticals LLC
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (31 Dec 1984),
Hypertension
Regulation-
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Structure/Sequence

Molecular FormulaC7H8ClN3O4S2
InChIKeyJZUFKLXOESDKRF-UHFFFAOYSA-N
CAS Registry58-93-5
View All Structures (2)

Related

3
Clinical Trials associated with Hydrochlorothiazide/Metoprolol Tartrate
NCT00649233
/ CompletedPhase 1
Single-Dose Food In Vivo Bioequivalence Study of Metoprolol Tartrate/Hydrochlorothiazide Tablets (100/50 mg; Mylan) to Lopressor HCT® Tablets (100/50 mg; Novartis) in Healthy Volunteers
NCT00649688
/ CompletedPhase 1
Single-Dose Fasting In Vivo Bioequivalence Study of Metoprolol Tartrate/Hydrochlorothiazide Tablets (100/50 mg; Mylan) and Lopressor HCT® Tablets (100/50 mg; Novartis) in Healthy Volunteers
ISRCTN58485613
/ CompletedNot ApplicableIIT
Efficacy of metoprolol CR/XL on diabetic postoperative mortality and cardiovascular morbidity: a randomised, double blind, placebo-controlled, multicentre trial
100 Clinical Results associated with Hydrochlorothiazide/Metoprolol Tartrate
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100 Translational Medicine associated with Hydrochlorothiazide/Metoprolol Tartrate
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100 Patents (Medical) associated with Hydrochlorothiazide/Metoprolol Tartrate
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100 Deals associated with Hydrochlorothiazide/Metoprolol Tartrate
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External Link

KEGGWikiATCDrug Bank
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C03AX01C07BB52
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R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
United States
Validus Pharmaceuticals LLCValidus Pharmaceuticals LLC
31 Dec 1984
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Clinical Result

Indication
Phase
Evaluation
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Clinical Trial

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Approval

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Regulation

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