Last update 26 Jul 2025

Efaprinermin alfa

Overview

Basic Info

Drug Type
Fc fusion protein
Synonyms
GITRL-Fc, GITRL-Fc trimer, OMP 336B11
+ [1]
Target
GITR
Action
agonists
Mechanism
GITR agonists(Glucocorticoid-induced tumor necrosis factor receptor-related protein agonists)
Therapeutic Areas
Neoplasms
Active Indication-
Inactive Indication
Locally Advanced Malignant NeoplasmLocally Advanced Malignant Solid NeoplasmNeoplasm Metastasis+ [1]
Originator Organization
Mereo BioPharma 5, Inc.Mereo BioPharma 5, Inc.
Active Organization-
Inactive Organization
Mereo BioPharma 5, Inc.Mereo BioPharma 5, Inc.
License Organization-
Drug Highest PhaseDiscontinuedPhase 1
First Approval Date-
Regulation-
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Structure/Sequence

Related

1
Clinical Trials associated with Efaprinermin alfa
NCT03295942
/ TerminatedPhase 1
A Phase 1a Open-Label, Dose Escalation Study of the Safety and Pharmacokinetics of OMP-336B11 Administered as a Single Agent to Subjects With Locally Advanced or Metastatic Solid Tumors
100 Clinical Results associated with Efaprinermin alfa
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100 Translational Medicine associated with Efaprinermin alfa
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100 Patents (Medical) associated with Efaprinermin alfa
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100 Deals associated with Efaprinermin alfa
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Locally Advanced Malignant NeoplasmPhase 1
United States
-12 Sep 2017
Locally Advanced Malignant Solid NeoplasmPhase 1
United States
-12 Sep 2017
Neoplasm MetastasisPhase 1
United States
-12 Sep 2017
NeoplasmsPreclinical
United States
Mereo BioPharma 5, Inc.Mereo BioPharma 5, Inc.
03 Jan 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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