Last update 08 May 2025

KrasG12D siRNA-loaded mesenchymal stromal cells-derived exosomes (Codiak BioSciences)

Overview

Basic Info

Drug Type
Exosomes, siRNA
Synonyms
MSC-derived Exosomes with KrasG12D siRNA(Codiak BioSciences), Mesenchymal Stromal Cells-derived Exosomes with KRAS G12D siRNA(Codiak BioSciences), iExosomes
Target
KRAS G12D
Action
inhibitors
Mechanism
KRAS G12D inhibitors(GTPase KRas G12D inhibitors)
Therapeutic Areas
NeoplasmsDigestive System DisordersEndocrinology and Metabolic Disease
Active Indication
Metastatic Pancreatic CancerMetastatic Pancreatic Ductal AdenocarcinomaPancreatic adenocarcinoma metastatic
Inactive Indication-
Originator Organization
MD Anderson Cancer Center Orlando
Active Organization
The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer Center
Inactive Organization
Codiak BioSciences, Inc.Codiak BioSciences, Inc.
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Structure/Sequence

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Related

1
Clinical Trials associated with KrasG12D siRNA-loaded mesenchymal stromal cells-derived exosomes (Codiak BioSciences)
NCT03608631
/ Active, not recruitingPhase 1IIT
Phase I Study of Mesenchymal Stromal Cells-Derived Exosomes With KrasG12D siRNA for Metastatic Pancreas Cancer Patients Harboring KrasG12D Mutation
100 Clinical Results associated with KrasG12D siRNA-loaded mesenchymal stromal cells-derived exosomes (Codiak BioSciences)
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100 Translational Medicine associated with KrasG12D siRNA-loaded mesenchymal stromal cells-derived exosomes (Codiak BioSciences)
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100 Patents (Medical) associated with KrasG12D siRNA-loaded mesenchymal stromal cells-derived exosomes (Codiak BioSciences)
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1
Literatures (Medical) associated with KrasG12D siRNA-loaded mesenchymal stromal cells-derived exosomes (Codiak BioSciences)
01 Jun 2017Nature
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
100 Deals associated with KrasG12D siRNA-loaded mesenchymal stromal cells-derived exosomes (Codiak BioSciences)
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Pancreatic Ductal AdenocarcinomaNDA/BLA
United States
Codiak BioSciences, Inc.Codiak BioSciences, Inc.
27 Jan 2021
Metastatic Pancreatic CancerPhase 1
United States
The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer Center
27 Jan 2021
Metastatic Pancreatic Ductal AdenocarcinomaPhase 1
United States
The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer Center
27 Jan 2021
Pancreatic adenocarcinoma metastaticPhase 1
United States
The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer Center
27 Jan 2021
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Clinical Result

Indication
Phase
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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