Last update 24 Feb 2026

PM-1016

Overview

Basic Info

Drug Type
Gene therapy
Synonyms
PM 1016, PM1016
Target
IL-2
Action
inhibitors, stimulants
Mechanism
IL-2 inhibitors(Interleukin-2 inhibitors), Cell death stimulants
Therapeutic Areas
NeoplasmsDigestive System Disorders
Active Indication
Advanced Malignant Solid NeoplasmAdvanced Hepatocellular CarcinomaHepatocellular Carcinoma
Inactive Indication-
Originator Organization
Biotheus, Inc.Biotheus, Inc.
Active Organization
TILT Biotherapeutics OyTILT Biotherapeutics Oy
Inactive Organization
Biotheus, Inc.Biotheus, Inc.
GenIbet Biopharmaceuticals SAGenIbet Biopharmaceuticals SA
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

4
Clinical Trials associated with PM-1016
CTR20222200
/ TerminatedPhase 1
评价PM8002注射液联合PM1016注射液二线治疗晚期肝细胞癌受试者的初步疗效及安全性的Ib期临床试验
[Translation] A phase Ib clinical trial to evaluate the preliminary efficacy and safety of PM8002 injection combined with PM1016 injection as a second-line treatment for subjects with advanced hepatocellular carcinoma
ChiCTR2200063086
/ Not yet recruitingPhase 1IIT
A phase Ib study to evaluate the preliminary efficacy and safety of PM8002 combined with PM1016 in the second-line treatment of advanced Hepatocellular Carcinoma (HCC)
CTR20210764
/ TerminatedPhase 1/2
评价编码 TNF-α 和 IL-2 的溶瘤腺病毒 PM1016 在晚期恶性实体瘤受试者中的耐受性、安全性及初步疗效的 I 期临床试验及在晚期恶性实体瘤中考察初步疗效的 IIa 期临床试验
[Translation] A Phase I clinical trial to evaluate the tolerability, safety and preliminary efficacy of oncolytic adenovirus PM1016 encoding TNF-α and IL-2 in subjects with advanced malignant solid tumors and a Phase IIa clinical trial to investigate preliminary efficacy in subjects with advanced malignant solid tumors
100 Clinical Results associated with PM-1016
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100 Translational Medicine associated with PM-1016
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100 Patents (Medical) associated with PM-1016
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100 Deals associated with PM-1016
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
China
-20 May 2021
Advanced Hepatocellular CarcinomaPhase 1
China
-22 Sep 2022
Hepatocellular CarcinomaIND Approval
China
TILT Biotherapeutics OyTILT Biotherapeutics Oy
18 Aug 2022
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Clinical Result

Indication
Phase
Evaluation
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Regulation

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