Last update 08 May 2025

R462-CPT2

Overview

Basic Info

Drug Type
Peptide drug conjugates
Synonyms-
Target
LGR4 x LGR5 x LGR6
Action
inhibitors, antagonists
Mechanism
LGR4 inhibitors(leucine rich repeat containing G protein-coupled receptor 4 inhibitors), LGR5 antagonists(Leucine-rich repeat-containing G-protein coupled receptor 5 antagonists), LGR6 antagonists(leucine rich repeat containing G protein-coupled receptor 6 antagonists)
Therapeutic Areas
NeoplasmsDigestive System Disorders
Active Indication
Colorectal Cancer
Inactive Indication-
Originator Organization
University of Texas Health Science Center at HoustonUniversity of Texas Health Science Center at Houston
Active Organization
University of Texas Health Science Center at HoustonUniversity of Texas Health Science Center at Houston
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Structure/Sequence

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Related

100 Clinical Results associated with R462-CPT2
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100 Translational Medicine associated with R462-CPT2
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100 Patents (Medical) associated with R462-CPT2
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1
Literatures (Medical) associated with R462-CPT2
Anti-tumor activity of camptothecin analog conjugate of a RSPO4-based peptibody targeting LGR4/5/6 in preclinical models of colorectal cancer
100 Deals associated with R462-CPT2
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Colorectal CancerPreclinical
United States
University of Texas Health Science Center at HoustonUniversity of Texas Health Science Center at Houston
28 Apr 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

No Data

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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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