Last update 24 Jan 2026

S-38844

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
S 38844, S38844
Target
HCN channels
Action
blockers
Mechanism
HCN channels blockers(Hyperpolarization-activated cyclic nucleotide-gated channel blockers)
Therapeutic Areas
Cardiovascular Diseases
Active Indication-
Inactive Indication
Cardiovascular DiseasesChronic heart failureLeft ventricular systolic dysfunction+ [1]
Originator Organization
Les Laboratoires Servier SASLes Laboratoires Servier SAS
Active Organization-
Inactive Organization
Bruker BioSpin MRI GmbH
Institut de Recherches Internationales ServierInstitut de Recherches Intern Servier
+ [2]
License Organization
Amgen, Inc.Amgen, Inc.Les Laboratoires Servier SASLes Laboratoires Servier SAS
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-

Related

3
Clinical Trials associated with S-38844
EUCTR2013-003000-39-BE
/ CompletedPhase 2
Evaluation of the pharmacodynamics, pharmacokinetics and safety of repeated escalating oral doses of S 38844 versus placebo in patients with chronic heart failure and left ventricular systolic dysfunction A phase II, randomised, double-blind, parallel-group, placebo controlled, international multicentre study
NL-OMON36850
/ CompletedNot Applicable
Excretion balance, pharmacokinetics and metabolism of S 38844 after single oral dose administration of [14C]-S 38844 in healthy male volunteers. - 14C-S 38844 ADME study
EUCTR2010-020197-42-DE
/ Not yet recruitingNot Applicable
Evaluation of the pharmacokinetics, pharmacodynamics and safety of repeated escalating oral doses of a slow release formulation of S 38844 in healthy male volunteersAn open-label, non-randomised, two-group three-period, monocentre study
100 Clinical Results associated with S-38844
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100 Translational Medicine associated with S-38844
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100 Patents (Medical) associated with S-38844
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100 Deals associated with S-38844
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic heart failurePhase 2
Hungary
Institut de Recherches Internationales Servier
20 Mar 2014
Left ventricular systolic dysfunctionPhase 2
Hungary
Institut de Recherches Intern Servier
20 Mar 2014
Cardiovascular DiseasesPhase 1
Netherlands
Institut de Recherches Internationales Servier
15 Jan 2013
Ventricular Dysfunction, LeftPreclinical
France
Institut National de la Santé et de la Recherche MédicaleInstitut National de la Santé et de la Recherche Médicale
01 Oct 2015
Ventricular Dysfunction, LeftPreclinical
France
Les Laboratoires Servier SASLes Laboratoires Servier SAS
01 Oct 2015
Ventricular Dysfunction, LeftPreclinical
Germany
Bruker BioSpin MRI GmbH
01 Oct 2015
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Clinical Result

Indication
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Evaluation
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Clinical Trial

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Approval

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Regulation

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