Delving into the Latest Updates on Drotaverine acephyllinate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Depogen

Target

nAChRα1/β1/δ/γ

Action

antagonists

Mechanism

AChR antagonists(Acetylcholine receptor; alpha1/beta1/delta/gamma antagonists)

Therapeutic Areas

Cardiovascular Diseases

Active Indication-

Inactive Indication

Peripheral Vascular Diseases

Originator Organization

Sanofi

Active Organization-

Inactive Organization

Nippon Zoki Pharmaceutical Co. Ltd.

SanofiChinoin Zrt.

License Organization-

Drug Highest PhaseDiscontinuedPhase 3

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC33H41N5O8

InChIKeyOUKQYSCCWVCDKU-UHFFFAOYSA-N

CAS Registry61954-97-0

An efficient domino reaction for synthesizing pyrrolo[2,1-a]isoquinolines from 1-aryl-3,4-dihydroisoquinolines and vinyl ethynyl ketones was reported.The chem. selectivity of vinyl ethynyl ketones; i.e., adduct formation by the double or triple bond were also reported.The reaction outcome depends on the solvent, temperature, microwave irradiation and catalyst.Donor substituents in the initial isoquinolines provided a regioselective addition to double or triple bonds.

01 Dec 2017·SYNTHESIS-STUTTGART

Domino Reactions of 1-Aroyl-3,4-dihydroisoquinolines with α,β-Unsaturated Aldehydes

Author: Varlamov, Alexey ; Anikina, Lada ; Voskressensky, Leonid ; Titov, Alexander ; Astakhov, Grigorii ; Borisova, Tatiana ; Dyachenko, Svetlana ; Matveeva, Maria

An efficient synthesis of pyrrolo[2,1-a]isoquinolines by a domino reaction from a variety of 3,4-dihydropyrrolo[2,1-a]isoquinolines and α,β-unsaturated aldehydes in the absence of catalyst in good yields under microwave irradiation, is reported.

01 Mar 2017·TETRAHEDRON LETTERS

A facile synthesis of 1-oxo-pyrrolo[2,1-a]isoquinolines

Author: Maria D. Matveeva ; Alexey V. Varlamov ; Tatiana N. Borisova ; Svetlana V. Dyachenko ; Alexander A. Titov ; Leonid G. Voskressensky ; Alexander V. Aksenov ; Viktor N. Khrustalev

The facile synthesis of 1-oxo-pyrrolo[2,1-a]isoquinolines from the reaction of 1-aroyl-3,4-dihydroisoquinolines and sym. alkynes in toluene is described.The novel compounds contain functional groups that are suitable for further modification.

100 Deals associated with Drotaverine acephyllinate

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