BACKGROUNDNon-pharmacological and non-psychological approaches to the treatment of post-traumatic stress disorder (PTSD) have often been excluded from systematic reviews and meta-analyses. Consequently, we know little regarding their efficacy.OBJECTIVETo determine the effect sizes of non-pharmacological and non-psychological treatment approaches for PTSD.METHODWe undertook a systematic review and meta-analyses following Cochrane Collaboration guidelines. A pre-determined definition of clinical importance was applied to the results and the quality of evidence was appraised using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.RESULTS30 randomised controlled trials (RCTs) of a range of heterogeneous non-psychological and non-pharmacological interventions (28 in adults, two in children and adolescents) were included. There was emerging evidence for six different approaches (acupuncture, neurofeedback, saikokeishikankyoto (a herbal preparation), somatic experiencing, transcranial magnetic stimulation, and yoga).CONCLUSIONSGiven the level of evidence available, it would be premature to offer non-pharmacological and non-psychological interventions routinely, but those with evidence of efficacy provide alternatives for people who do not respond to, do not tolerate or do not want more conventional evidence-based interventions. This review should stimulate further research in this area.

01 Jan 2014·Evidence-Based Complementary and Alternative MedicineQ4 · MEDICINE

Treatment of Posttraumatic Stress Disorder Using the Traditional Japanese Herbal Medicine Saikokeishikankyoto: A Randomized, Observer‐Blinded, Controlled Trial in Survivors of the Great East Japan Earthquake and Tsunami

Q4 · MEDICINE

ArticleOA

Author: Tanaka, Junichi ; Kaneko, Soichiro ; Iwasaki, Koh ; Kanemura, Seiki ; Yaegashi, Nobuo ; Nara, Masayuki ; Kuroda, Hitoshi ; Kagaya, Yutaka ; Kohzuki, Masahiro ; Ishii, Tadashi ; Monma, Yasutake ; Takayama, Shin ; Gunfan, Shen ; Takahashi, Satomi ; Numata, Takehiro

The Great East Japan earthquake and tsunami caused immense damage over a wide area of eastern Japan. Hence, many survivors are at high risk for posttraumatic stress disorder (PTSD). This randomized, observer‐blinded, controlled trial examined the efficacy and safety of the traditional Japanese herbal formula saikokeishikankyoto (SKK) in the treatment of PTSD among survivors of this disaster. Forty‐three participants with an Impact of Event Scale‐Revised (IES‐R) score ≥ 25 were randomized into SKK (n = 21) and control (n = 22) groups. The primary endpoint was the change in IES‐R scores from baseline till after 2 weeks of treatment. Intergroup statistical comparisons were performed. The magnitude of changes in total IES‐R scores differed significantly between the two groups (P < 0.001). Post hoc analysis showed that the total IES‐R score improved significantly in the SKK group from 49.6 ± 11.9 to 25.5 ± 17.0 (P < 0.001). Subscale scores improved significantly in the SKK group (avoidance, P = 0.003; hyperarousal, P < 0.001; intrusion, P < 0.001). Two‐week treatment with SKK significantly improved IES‐R scores among PTSD patients. This traditional medicine may be a valid choice for the treatment of psychological and physical symptoms in PTSD patients.

01 Sep 2011·Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society

[A case of drug-induced pneumonitis caused by saikokeishikankyoto].

Article

Author: Yoshimori, Kouzou ; Kudoh, Shoji ; Imai, Yohhei ; Morimoto, Kozo ; Kurashima, Atsuyuki ; Ogata, Hideo

We report a case of drug-induced pneumonitis caused by saikokeishikankyoto. A 68-year-old woman was admitted to our hospital complaining of dry cough, fever, and dyspnea after taking saikokeishikankyoto for 16 days. A chest radiograph showed widespread ground-glass shadows in both lung fields. Chest CT showed ground-glass opacities and thickening of the interlobular septum in both lung fields. Bronchoalveolar lavage fluids and transbronchial lung biopsy specimen showed findings consistent with drug-induced pneumonitis, therefore we diagnosed drug-induced pneumonitis caused by saikokeishikankyoto. Three years previously she had suffered from a similar illness after taking hangeshashinto. Ougon is suspected to be a causative component for her saikokeishikankyoto-induced pneumonitis, because it has been reported to be as a main cause for kampo-induced pneumonitis.

100 Deals associated with Chaihu Guizhi Ganjiang Decoction

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Indication	Country/Location	Organization	Date
Andropause	JP	Honzo Co., Ltd.	01 Oct 1986
Neurotic Disorders	JP	Honzo Co., Ltd.	01 Oct 1986
Sleep Initiation and Maintenance Disorders	JP	Honzo Co., Ltd.	01 Oct 1986

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