Delving into the Latest Updates on Sodium pyrophosphate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Angiocis

Target-

Action-

Mechanism-

Therapeutic Areas

Cardiovascular DiseasesCongenital DisordersHemic and Lymphatic Diseases+ [2]

Active Indication-

Inactive Indication

CalculiPseudoxanthoma Elasticum

Originator Organization-

Active Organization-

Inactive Organization

Bangalore Medical College & Research Institute

Tampere University Hospital

Drug Highest PhaseDiscontinuedPhase 2

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaH4Na4O7P2

InChIKeyWTXQIGCNRZDSJU-UHFFFAOYSA-N

CAS Registry7722-88-5

Pyrophosphate is an endogenous, non-toxic metabolite inhibiting soft tissue calcification. The aim of our study is to find optimal dosing and safety of oral disodium-PPi (Na2H2PPi). Absorption curves (pharmacokinetics), AUC0-t, Cmax and Tmax for PPi and phosphate will be provided for healthy controls and PXE-patients both fasting and with standard meal intake.

Start Date08 Dec 2020

Sponsor / Collaborator

Tampere University Hospital

[+2]

NCT02869308

/ Unknown statusNot ApplicableIIT

Determination of Left Ventricular Ejection Fraction Using Cardiac Angioscintigraphy: Comparison Between Measurements Obtained With Conventional Planar Scintigraphy (E-CAM Camera) and Tomoscintigraphy Recorded by a CZT Semiconductor Camera (D-SPECT)

The purpose is to determine whether measurements of left ventricular ejection fraction (LVEF) obtained with angiographies recorded by conventional Anger camera or D-SPECT camera are equivalent.
Secondary purposes are:
To evaluate the influence of cardiac activity recorded by D-SPECT camera on equivalences defined in primary purpose
To evaluate the influence of the indication for the examination with a distinct analysis of a group having the examination for a known or suspected cardiomyopathy (LVEF often abnormally low) and a group having the examination for a chemotherapy supervision with heart initially considered healthy (LVEF often normal).

Start Date01 Jan 2014

Sponsor / Collaborator

Centre Hospitalier Regional de Nancy

100 Clinical Results associated with Sodium pyrophosphate

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100 Translational Medicine associated with Sodium pyrophosphate

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100 Patents (Medical) associated with Sodium pyrophosphate

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4,785

Literatures (Medical) associated with Sodium pyrophosphate

01 Apr 2025·Journal of Environmental Chemical Engineering

Nanomorphic copper phosphate as a lightless catalyst for singlet oxygen generation: Mechanistic insights and comparative analysis

Author: Zhao, Yan ; Zhang, Liyuan ; Zang, Lin ; Pan, Mengting ; Cong, Weihao ; Kong, Weiheng

Singlet oxygen (¹O₂), a highly reactive oxygen species, possesses significant utility in the domains of chem. and materials science, with applications encompassing wastewater treatment, advanced battery fabrication and the degradation of organic pollutants.The generation of ¹O₂ is typically facilitated through specific processes such as photocatalytic reactions involving photosensitizers, electron transfer reactions, or enzymic catalysis.The production of ¹O₂ is challenging and its reactivity is constrained, thereby limiting its generation and applications.This study aims to surmount these limitations by investigating the exceptional capacity of a nanomorphic copper phosphate (Cu₃(PO₄)₂) to generate ¹O₂ in no need of light activation.A comprehensive characterization of the micromorphol., phys., and chem. properties of Cu₃(PO₄)₂ was conducted to analyze and evaluate its structural and intrinsic characteristics.Systematic research on the kinetic simulation properties of Cu₃(PO₄)₂ was undertaken to acquire exptl. data pertaining to the efficiency and mechanism of the catalytic process, providing a scientific foundation for further optimizing its performance as a catalyst for 1O2 generation.This research may pave the way for the development of novel and efficient systems for the generation of effective ¹O₂.

01 Apr 2025·Polymer Degradation and Stability

Biomass-derived polyelectrolyte fire retardant: Synergistic phosphorus-nitrogen doping for enhanced epoxy resin flame retardancy and smoke suppression

Author: Cui, Yumeng ; Sun, Jun ; Jiao, Yunhong ; Qu, Hongqiang ; Xu, Jianzhong ; Huo, Zhiyong ; Zhang, Ge

A bio-based polyelectrolyte based on chitosan (CS) and sodium pyrophosphate (TSPP) was synthesized (TSPP-CS) by coprecipitation method.The resulting flame retardant was then incorporated into epoxy resin (EP) composites to improve their flame retardant properties.The structure, morphol. and composition of the flame retardant were analyzed by Fourier transform IR spectroscopy (FT-IR), XPS, scanning electron microscope (SEM) and Inductive Coupled Plasma Emission Spectrometer (ICP).The flame retardancy of EP composites was evaluated using cone calorimeter (CCT) testing.The results showed that the addition of only 0.68 % P content to the system resulted in a significant reduction in the flame retardancy of the composites compared to neat EP.After combustion, the expansion height of the residual char is higher and more compact, and the degree of graphitization is improved, which provides better substrate protection.Addnl., the addition of TSPP-CS had a pos. impact on the mech. properties of EP.

01 Apr 2025·Biology and Fertility of Soils

Loading of redox-active metal Fe largely enhances the capacity of biochar to mitigate soil N2O emissions by promoting complete denitrification

Author: Qin, Shuping ; Wu, Ping ; Hu, Chunsheng ; Luo, Jiafa ; Yuan, Dan ; Tang, Jiahuan ; Jia, Zhifen ; Wrage-Monnig, Nicole ; Yuan, Jiao ; Clough, Tim J.

Nitrous oxide (N₂O) is a critical greenhouse gas and an ozone-depleting substance, with a global warming potential 298-310 times greater than that of CO₂.Mitigating N₂O emissions from soils has environmental benefits.Recent research indicates that biochar can serve as an ^"electron shuttle^" to reduce N₂O emissions from soils.Electron shuttle is defined as organic mols. capable of reversibly receiving and donating electrons.Thus, biochar is expected to facilitate stepwise reduction of denitrification products, reducing N₂O to environmentally harmless N₂.However, it remains uncertain whether biochar capacity to mitigate N₂O can be enlarged by augmenting its function as an electron shuttle.Thus, this study prepared a biochar with enhanced electron shuttle potential by loading redox-active (Fe) onto biochar.The effectiveness of this biochar in mitigating soil N₂O emissions was investigated by incorporating it into the soil.The results showed that Fe-loaded biochar significantly augmented its function as an electron shuttle and dramatically reduced soil N₂O emissions by 92% compared to the original biochar.The degree of decrease in N₂O emissions was strongly associated with both the electron shuttle capacity and the concentration of redox-active Fe in the biochar.Addnl., Fe-loaded biochar significantly decreased the N₂O/(N₂O + N₂) emission ratio and increased the expression of the nosZ-II gene.Our findings suggest that redox-active Fe loading in biochar is an effective strategy to enhance its electron shuttle function.The augmented electron shuttle function of biochar can successfully facilitate N₂O mitigation emission by promoting complete denitrification.

100 Deals associated with Sodium pyrophosphate

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