Delving into the Latest Updates on MSI 751 with Synapse

Overview

Basic Info

Drug Type

Synthetic peptide

Synonyms

Target-

Mechanism-

Therapeutic Areas

Infectious Diseases

Active Indication-

Inactive Indication

Mycoses

Originator Organization

Genaera Corp.

Active Organization-

Inactive Organization

Genaera Corp.

Drug Highest PhaseDiscontinuedPreclinical

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC26H46N4O

InChIKeyPEXYQRJOWGBEHF-DEOSSOPVSA-N

CAS Registry160802-86-8

Magainins are a family of potent antimicrobial cationic peptides that possess antimicrobial activity against a wide range of target organisms. In this study, the antimicrobial activity of synthetic magainin-mimetic compounds MSI-751 and MSI-774 was investigated against the periodontal pathogens Porphyromonas gingivalis, Fusobacterium nucleatum, Actinobacillus actinomycetemcomitans, Eikenella corrodens, Prevotella loescheii and Prevotella intermedia. P. gingivalis was more susceptible to MSI-751 than to MSI-774, whereas the other oral pathogens showed little difference in susceptibility to the two compounds. MSI-751 exhibited a rapid, dose-dependent bactericidal effect on P. gingivalis. Electron microscopy of MSI-751-treated P. gingivalis revealed intact cell wall vesicles devoid of cell contents, suggesting perturbation of the cytoplasmic membrane by this compound, perhaps equivalent to formation of membrane-disruptive ion channels by magainin peptides. These studies demonstrate that synthetic magainin derivatives exhibit antimicrobial activity against oral pathogens by disruption of cell membrane integrity.

100 Deals associated with MSI 751

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