Delving into the Latest Updates on AOD113408 with Synapse

Overview

Basic Info

Drug Type

Chemical drugs

Synonyms

AOD113408

Target

GCGR x GLP-1R

Action

agonists

Mechanism

GCGR agonists(Glucagon receptor agonists), GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)

Therapeutic Areas

Digestive System Disorders

Active Indication

Nonalcoholic Steatohepatitis

Inactive Indication-

Originator Organization

Chengdu Aoda Biotechnology Co., Ltd.

Active Organization

Chengdu Aoda Biotechnology Co., Ltd.

Inactive Organization-

License Organization-

Drug Highest PhasePhase 1

First Approval Date-

Regulation-

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[Translation] A randomized, double-blind, placebo-controlled, dose-escalating phase I clinical study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of AOD113408 injection after single subcutaneous administration in healthy subjects and multiple subcutaneous administration in overweight or obese subjects

主要目的：评价AOD113408注射液在健康受试者单次和在超重或肥胖受试者中多次皮下注射的安全性和耐受性次要目的：（1）评价AOD113408注射液在健康受试者中单次和在超重或肥胖受试者中多次皮下注射的药代动力学特征（2）评价AOD113408注射液在健康受试者中单次和在超重或肥胖受试者中多次皮下注射的药效动力学特征（3）评价AOD113408注射液在健康受试者中单次和在超重或肥胖受试者中多次皮下注射的免疫原性

[Translation]

Primary objectives: To evaluate the safety and tolerability of AOD113408 injection after single and multiple subcutaneous injections in healthy subjects Secondary objectives: (1) To evaluate the pharmacokinetic characteristics of AOD113408 injection after single and multiple subcutaneous injections in healthy subjects (2) To evaluate the pharmacodynamic characteristics of AOD113408 injection after single and multiple subcutaneous injections in healthy subjects (3) To evaluate the immunogenicity of AOD113408 injection after single and multiple subcutaneous injections in healthy subjects

Start Date-

Sponsor / Collaborator

Chengdu Aoda Biotechnology Co., Ltd.

100 Clinical Results associated with AOD113408

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100 Translational Medicine associated with AOD113408

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100 Patents (Medical) associated with AOD113408

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100 Deals associated with AOD113408

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