Last update 17 Apr 2025

KH815

Overview

Basic Info

Drug Type
Dual payload Antibody drug conjugate (Dual payload ADC)
Synonyms
KH815
Target
POLR2A x Top I x Trop-2
Action
inhibitors
Mechanism
POLR2A inhibitors(DNA-directed RNA polymerase II subunit RPB1 inhibitors), TOP1 inhibitors(DNA topoisomerase I inhibitors), Trop-2 inhibitors(Tumor-associated calcium signal transducer 2 inhibitors)
Therapeutic Areas
Neoplasms
Active Indication
Advanced Malignant Solid NeoplasmNeoplasms
Inactive Indication-
Originator Organization
Chengdu Kanghong Biotechnologies Co., Ltd.Chengdu Kanghong Biotechnologies Co., Ltd.
Active Organization
Kanghong Biotechnology Group Co., Ltd.Chengdu Kanghong Biotechnologies Co., Ltd.Chengdu Kanghong Biotechnologies Co., Ltd.
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Structure/Sequence

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Related

1
Clinical Trials associated with KH815
NCT06885645
/ Not yet recruitingPhase 1
A Phase 1 Study of KH815 for Injection to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumor Activity in Patients With Advanced Solid Tumors
100 Clinical Results associated with KH815
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100 Translational Medicine associated with KH815
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100 Patents (Medical) associated with KH815
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100 Deals associated with KH815
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 1-
Chengdu Kanghong Biotechnologies Co., Ltd.Chengdu Kanghong Biotechnologies Co., Ltd.
30 Apr 2025
NeoplasmsPreclinical
China
Kanghong Biotechnology Group Co., Ltd.
28 Apr 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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