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Clinical Trials associated with Dendritic cells vaccine(Universidad de Navarra)Dendritic Cell-based Immunotherapy for Advanced Solid Tumours of Children and Young Adults
Phase I/II, open, prospective clinical trial, historically controlled. The objective is to evaluate the safety and, as a secondary measure, the efficacy of an experimental treatment based on a cellular therapy (vaccination with autologous dendritic cells pulsed with tumor lysate) in patients affected of metastatic or relapsed sarcomas or (Central Nervous System) CNS tumors.
Phase II Study With Hiltonol and Dendritic Cells in Solid Tumors
In this phase II study, patients with solid tumors will receive treatment with hiltonol and autologous dendritic cells.
Prospective, Phase II Clinical Trial to Evaluate Efficacy and Safety of Autologous Dendritic Cell Vaccination in Glioblastoma Multiforme Patients After Complete Surgical Resection With Fluorescence Microscope
Primary outcome measure:
a.Evaluation of the treatment impact on progression-free survival.
Secondary outcome measures:
Safety evaluation.
Direct effects attributable cell obtaining and administration.
Adverse events during treatment.
Neurological deterioration quantified using the NIH Stroke Scale.
Autoimmune phenomena.
Evaluation of impact on other efficiency clinical parameters.
Overall survival.
Quality of life measured with EORTC questionnaire.
Study of specific immune response and correlates with clinical outcome.
Delayed hypersensitivity.
Humoral response to autologous tumor cells/tumoral lysate.
Cellular response (proliferation, cytokine production, specific cytotoxicity).
Cell line characterization and correlate the final product with clinical efficacy.
Phenotypic studies.
100 Clinical Results associated with Dendritic cells vaccine(Universidad de Navarra)
100 Translational Medicine associated with Dendritic cells vaccine(Universidad de Navarra)
100 Patents (Medical) associated with Dendritic cells vaccine(Universidad de Navarra)
100 Deals associated with Dendritic cells vaccine(Universidad de Navarra)