This study is to evaluate whether intraoperative fluorescence imaging targeting GPC3 can aid improve the surgical accuracy of hepatocellular carcinoma.
The main purposes of this study include:
① To raise the detection rate of hepatocellular carcinoma intraoperatively using the novel NIR-II fluorescence molecular imaging and the GPC-3 targeted fluorophore.
② To validate the safety and effectiveness of the designed GPC-3 targeted fluorophore for clinical application.

Start Date10 Sep 2021

Sponsor / Collaborator

Chinese Academy of Sciences

NCT03407781 / CompletedPhase 1

IRDye800CW-BBN PET-NIRF in Lower Grade Glioma

This is an open-label positron emission tomography/near infrared (PET/NIRF) study to investigate the imaging navigation performance and evaluation efficacy of dual modality imaging probe 68Ga-BBN-IRDye800CW in patients with lower grade glioma. A single dose of 40μg/111-148 Mega-Becquerel (MBq) 68Ga-NOTA-BBN and 1.0- or 2.0- mg/ml IRDye800CW-BBN will be injected intravenously before the operation and intraoperative respectively. Visual and semiquantitative method will be used to assess the PET images and real-time margins localization for surgical navigation.

Start Date01 Jan 2016

Sponsor / Collaborator

Chinese Academy of Sciences

[+2]

NCT02910804 / Unknown statusEarly Phase 1IIT

PET-NIRF Dual Modality Imaging Guiding Surgery in Patients With Glioblastoma

This is an open-label positron emission tomography/near infrared (PET/NIRF) study to investigate the imaging navigation performance and evaluation efficacy of dual modality imaging probe 68Ga-BBN-IRDye800CW in glioblastoma (GBM) patients. A single dose of 40μg/111-148 Mega-Becquerel (MBq) and 1.0 mg/ml 68Ga-BBN-IRDye800CW will be injected intravenously before the operation and intraoperative respectively. Visual and semiquantitative method will be used to assess the PET images and real-time margins localization for surgical navigation.

Start Date01 Nov 2015

Sponsor / Collaborator

Beijing Tiantan Hospital

[+3]

100 Clinical Results associated with 68Ga-BBN-IRDye800CW

100 Translational Medicine associated with 68Ga-BBN-IRDye800CW

100 Patents (Medical) associated with 68Ga-BBN-IRDye800CW

100 Deals associated with 68Ga-BBN-IRDye800CW

R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Glioblastoma	Phase 1	-	Chinese Academy of Sciences	-
Glioblastoma	Phase 1	-	Beijing Tiantan Hospital	-
Glioblastoma	Phase 1	-	National Institute For Biomedical Imaging And Bioengineering (Nibib)	-
Low grade glioma	Preclinical	CN	National Institute For Biomedical Imaging And Bioengineering (Nibib)	01 Jan 2016

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