Last update 01 Nov 2024
Aliskiren Hemifumarate/Amlodipine Besilate/Hydrochlorothiazide
Last update 01 Nov 2024
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms Aliskiren/Amlodipine/Hydrochlorothiazide, Amlodipine/aliskiren/hydrochlorothiazide, Amlodipine/hydrochlorothiazide/aliskiren + [5] |
Target |
Mechanism NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors), VDCCs blockers(Voltage-gated calcium channel blockers), renin inhibitors(Renin inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseWithdrawn |
First Approval Date US (21 Dec 2010), |
Regulation- |
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Structure
Molecular FormulaC7H8ClN3O4S2 |
InChIKeyJZUFKLXOESDKRF-UHFFFAOYSA-N |
CAS Registry58-93-5 |
View All Structures (3)
Related
2
Clinical Trials associated with Aliskiren Hemifumarate/Amlodipine Besilate/HydrochlorothiazideAn Open-label, Multicenter Study to Evaluate the Efficacy and Safety of a 4 Week Therapy With the Single Pill (SPC) Combination of Aliskiren 300 mg / Amlodipine 10 mg in Hypertensive Patients Not Adequately Respond to an Uptitrated 4 Week Therapy With the SPC of Olmesartan 40 mg / Amlodipine 10 mg, With a Potential Extension if Patients Still Not Adequately Respond With a 4 Week Therapy With the SPC Aliskiren 300 mg / Amlodipine 10 mg / HCTZ 12,5 mg
Multi-center, Open Label, 18-week Study to Demonstrate the Efficacy and Safety of Combination Therapy of Aliskiren/Amlodipine or Aliskiren/Amlodipine/Hydrochlorothiazide in Patients With Stage II HT
100 Clinical Results associated with Aliskiren Hemifumarate/Amlodipine Besilate/Hydrochlorothiazide
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100 Translational Medicine associated with Aliskiren Hemifumarate/Amlodipine Besilate/Hydrochlorothiazide
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100 Patents (Medical) associated with Aliskiren Hemifumarate/Amlodipine Besilate/Hydrochlorothiazide
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100 Deals associated with Aliskiren Hemifumarate/Amlodipine Besilate/Hydrochlorothiazide
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External Link
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
R&D Status
10 top approved records. to view more data
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| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Essential Hypertension | EU | 22 Nov 2011 | |
| Essential Hypertension | IS | 22 Nov 2011 | |
| Essential Hypertension | LI | 22 Nov 2011 | |
| Essential Hypertension | NO | 22 Nov 2011 | |
| Hypertension | US | 21 Dec 2010 |
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