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Clinical Trials associated with Chimeric exosomal tumor vaccines(Shanghai Pudong Hospital) / Unknown statusEarly Phase 1IIT An Open, Dose-escalation Clinical Study of Chimeric Exosomal Tumor Vaccines for Recurrent or Metastatic Bladder Cancer
1. Based on the applicant's previous work and combined with the clinical medical resources of our unit, tumor cells were isolated from the lesion site of cancer patients, dendritic cells or macrophages were isolated from peripheral blood, and personalized chimeric exosome vaccine was prepared for patients.
2. To evaluate the safety and tolerability of multiple administration of chimeric exosome vaccine in subjects with hatching or metastatic bladder cancer, explore the maximum tolerated dose (MDT) and dose-limiting toxicity (DLT) in humans, and recommend the safe dose range for the subsequent extended trials and subsequent clinical studies of this product.
3. To reveal the "double-effect" improvement mechanism of chimeric exosome vaccine on the activation of immune response and the microenvironment of bladder cancer lesions, improve the anti-recurrence treatment effect of bladder cancer, and realize the clinical transformation of "double-target and double-effect" chimeric exosome vaccine in the field of individualized precision treatment of bladder cancer patients.
4. To explore the clinical application value of this tumor therapeutic vaccine by using the T-cell receptor immunoomics and immunomolecular evaluation technology platform established by previous researchers, and to provide preliminary clinical research results for further vaccine development.
100 Clinical Results associated with Chimeric exosomal tumor vaccines(Shanghai Pudong Hospital)
100 Translational Medicine associated with Chimeric exosomal tumor vaccines(Shanghai Pudong Hospital)
100 Patents (Medical) associated with Chimeric exosomal tumor vaccines(Shanghai Pudong Hospital)
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Literatures (Medical) associated with Chimeric exosomal tumor vaccines(Shanghai Pudong Hospital)01 Nov 2020·Bundesgesundheitsblatt - Gesundheitsforschung - GesundheitsschutzQ4 · MEDICINE
Kombinationstherapien in der Immunonkologie: Differenzierte regulatorische Herangehensweisen
Q4 · MEDICINE
Review
Author: Sarac, Sinan B ; Schüssler-Lenz, Martina ; Müller-Berghaus, Jan
01 Jul 2020·Der InternistQ4 · MEDICINE
Tumorvakzinierung – therapeutische Vakzinierung gegen Krebs
Q4 · MEDICINE
Review
Author: Gouttefangeas, C ; Löffler, M W ; Walz, J S ; Haen, S P ; Rammensee, H-G ; Bokemeyer, C
01 Feb 2011·DMW - Deutsche Medizinische WochenschriftQ4 · MEDICINE
Plasmide, Vektoren, Tumorvakzine - neue Impfkonzepte in der Diskussion
Q4 · MEDICINE
Article
Author: Bruhn, Claudia
100 Deals associated with Chimeric exosomal tumor vaccines(Shanghai Pudong Hospital)