[Translation] A single-center, randomized, double-blind, placebo-controlled, phase I clinical trial of the pharmacokinetic efficacy of ZN2007Na tablets in healthy subjects and in combination with ritonavir
(1)评价ZN2007Na片在健康受试者中单次给药的安全性和耐受性、药代动力学特征,以及食物对药代动力学的影响。 (2)评价ZN2007Na片在健康受试者中多次给药的安全性和耐受性,药代动力学特征。 (3)评价ZN2007Na片联合利托那韦在健康受试者中单次、多次给药的安全性和耐受性,药代动力学特征,药物代谢转化研究。
[Translation] (1) To evaluate the safety and tolerability of single-dose ZN2007Na tablets, their pharmacokinetic characteristics, and the effect of food on pharmacokinetics in healthy subjects. (2) To evaluate the safety and tolerability of multiple-dose ZN2007Na tablets, their pharmacokinetic characteristics, and the pharmacokinetic transformation of ZN2007Na tablets in healthy subjects. (3) To evaluate the safety and tolerability of single-dose and multiple-dose ZN2007Na tablets combined with ritonavir, their pharmacokinetic characteristics, and drug metabolism transformation studies in healthy subjects.