Delving into the Latest Updates on ORIC-1940 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

ORIC-1940

Target

RIPK1

Action

inhibitors

Mechanism

RIPK1 inhibitors(Receptor-interacting serine/threonine-protein kinase 1 inhibitors)

Therapeutic Areas

Hemic and Lymphatic DiseasesOther Diseases

Active Indication

Lymphohistiocytosis, Hemophagocytic

Inactive Indication-

Originator Organization

Chengdu Ori Pharmaceutical Co., Ltd.

Active Organization

Chengdu Ori Pharmaceutical Co., Ltd.

Inactive Organization-

License Organization-

Drug Highest PhasePhase 1

First Approval Date-

Regulation-

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1.评价ORIC-1940在中国噬血细胞性淋巴组织细胞增多症（hemophagocytic lymphohistiocytosis, HLH）经治患者中的安全性和耐受性。 2.评价ORIC-1940在中国HLH经治患者中的初步疗效，确定II期推荐剂量（recommended phase 2 dose, RP2D） 3.评价ORIC-1940在中国HLH经治患者中的PK/PD特征

[Translation]

1. Evaluate the safety and tolerability of ORIC-1940 in Chinese patients with hemophagocytic lymphohistiocytosis (HLH) who have been treated. 2. Evaluate the preliminary efficacy of ORIC-1940 in Chinese patients with HLH who have been treated and determine the recommended phase 2 dose (RP2D) 3. Evaluate the PK/PD characteristics of ORIC-1940 in Chinese patients with HLH who have been treated

Start Date-

Sponsor / Collaborator

Chengdu Ori Pharmaceutical Co., Ltd.

CTR20242774

/ Not yet recruitingPhase 1

评价注射用盐酸ORIC-1940在中国健康成人志愿者中单次/多次给药的安全性、耐受性及PK/PD特征的Ia期临床研究

[Translation] A Phase Ia clinical study to evaluate the safety, tolerability and PK/PD characteristics of single/multiple doses of ORIC-1940 hydrochloride for injection in healthy Chinese adult volunteers

1.评价中国健康成人志愿者中ORIC-1940单次/多次给药的安全性及耐受性； 2.评价中国健康成人志愿者中ORIC-1940单次/多次给药的PK/PD特征。

[Translation]

1. Evaluate the safety and tolerability of single/multiple administration of ORIC-1940 in healthy Chinese adult volunteers; 2. Evaluate the PK/PD characteristics of single/multiple administration of ORIC-1940 in healthy Chinese adult volunteers.

Start Date-

Sponsor / Collaborator

Chengdu Ori Pharmaceutical Co., Ltd.

100 Clinical Results associated with ORIC-1940

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100 Translational Medicine associated with ORIC-1940

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100 Patents (Medical) associated with ORIC-1940

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100 Deals associated with ORIC-1940

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