Delving into the Latest Updates on MU1787 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target

HIPK

Action

inhibitors

Mechanism

HIPK inhibitors(HIPK subfamily inhibitors)

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization

Masaryk University

Active Organization

Masaryk University

Inactive Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

The furo [3,2-b]pyridine motif represents a relatively underexplored central pharmacophore in the area of kinase inhibitors. Herein, we report flexible synthesis of 3,5-disubstituted furo [3,2-b]pyridines that relies on chemoselective couplings of newly prepared 5-chloro-3-iodofuro [3,2-b]pyridine. This methodology allowed efficient second-generation synthesis of the state-of-the-art chemical biology probe for CLK1/2/4 MU1210, and identification of the highly selective inhibitors of HIPKs MU135 and MU1787 which are presented and characterized in this study, including the X-ray crystal structure of MU135 in HIPK2. chemical biology probe.

100 Deals associated with MU1787

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