Delving into the Latest Updates on Nitrofurantoin Sodium with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Ivadantin

Target-

Action-

Mechanism-

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization

Procter & Gamble Pharmaceuticals, Inc.

Active Organization-

Inactive Organization

Procter & Gamble Pharmaceuticals, Inc.

License Organization-

Drug Highest PhaseWithdrawn

First Approval Date

United States (15 Sep 1960)

Regulation-

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Nitrofurantoin sodium and nitorfurazone, in certain critical concentrations, have the ability to immobilize spermatozoa. In this study, this effect was consisitent with both 5:1, and 10:1 dilutions. Histologic examination of the effects of these drugs as intraoperative vas irrigants revealed no apparent tissue toxicity in the guinea pig. Clinically, we found intraoperative vas irrigation with both of these nontoxic drugs to be of value in attaining azoospermia immediately postvasectomy. Therefore, they appear to be useful supplements to vasectomy.

01 Jan 1975·Journal of UrologyQ1 · MEDICINE

The Nitrofurans as Sperm Immobilizing Agents

Q1 · MEDICINE

Article

Author: Albert, Peter S. ; Kapoor, Shailendra N. ; Salerno, Richard G. ; Davis, Joseph E.

In certain critical concentrations nitrofurantoin sodium and nitrofurazone cause sperm immobilization. Intraoperative was irrigation with these solutions in 16 patients produced sterility in the immediate postoperative period. This procedure minimizes time-consuming postoperative sperm analyses. Moreover, in underdeveloped countries where postoperative followup is difficult to obtain, this procedure would provide an additional positive factor in an attempt to ensure sterility.

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