Rationale:Antibiotic-associated hemorrhagic colitis (AAHC) is a special type of antibiotic-associated colitis. Due to the increased use of antibiotics, especially amoxicillin, which is commonly used in clinical practice, the incidence of antibiotic-associated hemorrhagic colitis has also increased. However, doctors have insufficient understanding of this disease, and patients may be missed or misdiagnosed.Patient concerns:A 71-year-old female patient was admitted to our hospital with abdominal pain, diarrhea, and bloody stools. There was a history of oral amoxicillin before the onset of the disease.Diagnosis:The final diagnosis of this patient was amoxicillin-associated hemorrhagic colitis.Interventions:The patient stopped using antibiotics and was given “Bifidobacterium quadruplex live bacterial tablets and L-glutamine sodium gualenate granules” orally.Outcomes:After oral administration, the patient’s symptom rapidly were completely alleviate. Follow-up colonoscopy revealed normal mucosal images.Lesson:Through this case report, doctors should increase their understanding of the disease, especially for patients with sudden abdominal pain accompanied by bloody stools as the main complaint, it is significant to attend to inquiries about the history of antibiotic use, such as amoxicillin, and pay attention to the discovery of acid-producing Klebsiella in the fecal microbiota.

07 Apr 2022·Evidence-Based Complementary and Alternative MedicineQ4 · MEDICINE

Efficacy and Safety of Zuojin Pill for the Treatment of Chronic Nonatrophic Gastritis: A Randomized Active-Controlled Clinical Trial

Q4 · MEDICINE

ArticleOA

Author: Jing, Jing ; Cui, Yanfei ; Ma, Xiao ; Wang, Zhongxia ; He, Tingting ; Tian, Miao ; Yuan, Zongyang ; Rong, Wenya ; Lu, Zheng ; Zhao, Yanling ; Wang, Yanling ; Wang, Ruilin

Objective. Zuojin pill (ZJP) is used as the classical prescription for a wide variety of digestive diseases. However, there is a lack of direct evidence for its use in the treatment of chronic nonatrophic gastritis (CNG). In particular, there is a lack of rigorous trials of randomized controlled designs. In this study, a randomized active-controlled clinical trial was performed to verify the efficacy and safety of ZJP in detail. Methods. Patients with CNG were divided into the ZJP group and the Marzulene-S granule group. Patients were enrolled from September 2019 to February 2021 (ChiCTR2000040549). Endoscopy and histology scores were evaluated as the primary outcome measure. The Helicobacter pylori positive rate and the disappearance rate of symptoms were also measured to reflect the outcomes. Finally, adverse events were also calculated as the index of safety. Results. A total of 68 eligible patients were enrolled in this trial and randomly divided into two groups with baseline comparability. ZJP was able to improve the red plaques as well as bile reflux scores compared with Marzulene-S granule (

P = 0.043

and

P = 0.019

, respectively). Moreover, it also remarkably alleviated the active chronic inflammation score

(P = 0.043)

. However, there was no difference between the Helicobacter pylori positivity rate

(P = 0.752)

. The symptom scores of abdominal distension

(P = 0.004)

, belching

(P = 0.010)

, and loss of appetite

(P = 0.019)

were alleviated by ZJP, but nausea and vomiting were not

(P = 0.616)

. ZJP can also be considered safe with no obvious adverse effects. Conclusion. ZJP might decrease mucosal injury and alleviate symptoms in CNG. In addition, more large-scale clinical trials should be carried out to further confirm its clinical efficacy and safety.

01 Jan 2010·LuminescenceQ4 · CHEMISTRY

The determination of glutamine with flow‐injection chemiluminescence detection and mechanism study

Q4 · CHEMISTRY

Article

Author: Zhuan-Li Liu ; Yan-Mei Shi ; Wei Tian ; Yan-Ming Liu

AbstractThe main purpose of this study was to develop an inexpensive, simple, rapid and sensitive chemiluminescence (CL) method for the determination of glutamine (Gln) using a flow‐injection (FI) system. Gln was found to strongly inhibit the CL signal of the luminol–H2O2–CuSO4 system in Na2B4O7 solution. A new FI‐CL method was developed for the determination of Gln. Parameters affecting the reproducibility and CL detection were optimized systematically. Under the optimized conditions, the corresponding linear regression equation was established over the range of 5.0 × 10−7 to 2.5 × 10−6 mol/L with the detection limit of 1.8 × 10−8 mol/L. The relative standard deviation was found to be 1.8% for 11 replicate determinations of 1.5 × 10−6 mol/L Gln. The proposed method has been satisfactorily applied for the determination of Gln in real samples (Marzulene‐s granules) with recoveries in the range of 98.7–108.6%. The minimum sampling rate was about 100 samples/h. The possible mechanism of this inhibitory CL was studied by fluorescence spectrophotometer and UV–vis spectrophotometer. Copyright © 2009 John Wiley & Sons, Ltd.

100 Deals associated with Sodium Azulene Sulfonate hydrate/Glutamine

External Link

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R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Duodenal Ulcer	JP	Kotobuki Pharmaceutical Co. Ltd.	05 May 1969
Gastritis	JP	Kotobuki Pharmaceutical Co. Ltd.	05 May 1969
Stomach Ulcer	JP	Kotobuki Pharmaceutical Co. Ltd.	05 May 1969

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