Last update 24 Mar 2025

HPB-001

Overview

Basic Info

Drug Type
Proteolysis-targeting chimeras (PROTAC)
Synonyms
ARB-085, HPB-001, PB-001
Target
EGFR exon 20
Action
inhibitors
Mechanism
EGFR exon 20 inhibitors(EGFR exon 20 Mutation inhibitors), Proteolysis
Therapeutic Areas
NeoplasmsRespiratory Diseases
Active Indication-
Inactive Indication
NeoplasmsNon-Small Cell Lung Cancer
Originator Organization
Arbella Therapeutics LLCDana-Farber Cancer Institute, Inc.Dana-Farber Cancer Institute, Inc.
Active Organization-
Inactive Organization
Dana-Farber Cancer Institute, Inc.Dana-Farber Cancer Institute, Inc.Arbella Therapeutics LLCHangzhou Duoyu Biotechnology Co., LtdHangzhou Duoyu Biotechnology Co., Ltd
Drug Highest PhasePendingPreclinical
First Approval Date-
Regulation-

Related

100 Clinical Results associated with HPB-001
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100 Translational Medicine associated with HPB-001
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100 Patents (Medical) associated with HPB-001
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100 Deals associated with HPB-001
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
NeoplasmsPreclinical
China
Hangzhou Duoyu Biotechnology Co., LtdHangzhou Duoyu Biotechnology Co., Ltd
15 May 2021
Non-Small Cell Lung CancerPreclinical
United States
Arbella Therapeutics LLC
15 May 2021
Non-Small Cell Lung CancerPreclinical
United States
Dana-Farber Cancer Institute, Inc.Dana-Farber Cancer Institute, Inc.
15 May 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Clinical Trial

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Approval

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Regulation

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