Delving into the Latest Updates on Sitostanol ester (Raisio Group/McNeil Consumer Healthcare) with Synapse

Overview

Basic Info

Drug Type

Chemical drugs

Synonyms

Benecol

Target

Cholesterol

Action

inhibitors

Mechanism

Cholesterol inhibitors

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication

HypercholesterolemiaNutrition Disorders

Inactive Indication-

Originator Organization

Raisio Oyj

Active Organization

McNeil Consumer HealthcareRaisio Oyj

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

Finland (05 Mar 1999),

HypercholesterolemiaNutrition Disorders

Regulation-

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People often hold unduly positive expectations about the outcomes of medicines and other healthcare products. Here the following explanation is tested: people who have a positive outcome tend to tell more people about their disease/treatment than people with poor or average outcomes. Akin to the file drawer problem in science, this systematically and positively distorts the information available to others.

METHOD:

If people with good treatment outcomes are more inclined to tell others, then they should also be more inclined to write online medical product reviews. Therefore, average treatment outcomes in these reviews should be more positive than those found in randomised controlled trials (RCTs). Data on duration of treatment and outcome (i.e., weight/cholesterol change) were extracted from user-generated health product reviews on Amazon.com and compared to RCT data for the same treatments using ANOVA. The sample included 1675 reviews of cholesterol reduction (Benecol, CholestOff) and weight loss (Orlistat) treatments and the primary outcome was cholesterol change (Bencol and CholestOff) or weight change (Orlistat).

RESULTS:

In three independent tests, average outcomes reported in the reviews were substantially more positive than the outcomes reported in the medical literature (η² = 0.01 to 0.06; p = 0.04 to 0.001). For example, average cholesterol change following use of Benecol is -14 mg/dl in RCTs and -45 mg/dl in online reviews.

CONCLUSIONS:

People with good treatment outcomes are more inclined to share information about their treatment, which distorts the information available to others. People who rely on word of mouth reputation, electronic or real life, are likely to develop unduly positive expectations.

01 Dec 2014·Lipids in health and diseaseQ3 · MEDICINE

Efficacy of yogurt drink with added plant stanol esters (Benecol®, Colanta) in reducing total and LDL cholesterol in subjects with moderate hypercholesterolemia: a randomized placebo-controlled crossover trial NCT01461798

Q3 · MEDICINE

ArticleOA

Author: Johanna Romero-Palacio ; Elsa M Vásquez-Trespalacios

BACKGROUND:

Cardiovascular diseases have become the leading cause of death from chronic diseases in the world. Main risk factors include hypercholesterolemia, which is caused in most cases by a high saturated fat diet. Plant stanol esters partly block cholesterol absorption in the digestive tract and thereby reduce total cholesterol and low-density lipoprotein (LDL) cholesterol serum levels. Based on epidemiological data, a 10 percent reduction of LDL cholesterol leads to a 20 percent decrease in the coronary heart disease risk throughout life. The aim of this study was to evaluate the efficacy of yogurt drink with added plant stanol esters (Benecol® yogurt drink) in higher doses than the typically used (2g/d stanols), in lowering blood lipids in moderately hypercholesterolemic subjects.

METHODS:

A randomized double-blind crossover, placebo-controlled study in moderately hypercholesterolemic subjects (n = 40) aged between 20 and 50 years old.

RESULTS:

Yogurt drink with added plant stanols (4 g) as esters (Benecol®, Colanta) consumption compared to regular yogurt drink caused a statistically significant decrease in total cholesterol and low density lipoprotein cholesterol by 7.2% and 10.3%. During the two periods and compared to controls, high-density lipoprotein cholesterol and triglycerides were not significantly different.

CONCLUSIONS:

Yogurt drink with an active ingredient in Benecol®, plant stanol esters, reduced total cholesterol and LDL cholesterol in moderately hypercholesterolemic subjects.

TRIAL REGISTRATION:

NCT01461798.

01 Dec 2006·AtherosclerosisQ2 · MEDICINE

Sterol esters, stanol esters, and vascular disease

Q2 · MEDICINE

Letter

Author: Joel A. Simon

A polemics in response to Patel and Thompson (ibid., 2006, 186, 1, 12-19) is presented.In their review of phytosterols and vascular disease, Patel and Thompson note that Take Control and Benecol margarines contain stanol and sterol esters, resp.In fact, Take Control contains sterol esters and Benecol contains stanol esters.One potentially important point not touched in the review is the difference in the absorption of sterol esters and stanol esters.

100 Deals associated with Sitostanol ester (Raisio Group/McNeil Consumer Healthcare)

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