Last update 08 May 2025

BMS-986449

Overview

Basic Info

Drug Type
Molecular glue
Synonyms
Target
IKZF2 x IKZF4
Action
degraders, inhibitors
Mechanism
IKZF2 degraders(Zinc finger protein helios degraders), IKZF4 inhibitors(IKAROS family zinc finger 4 inhibitors)
Therapeutic Areas
Neoplasms
Active Indication
Advanced Malignant Solid Neoplasm
Inactive Indication-
Originator Organization
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
Active Organization
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with BMS-986449
NCT05888831
/ RecruitingPhase 1/2
A Phase 1/2 Study of BMS-986449 Alone and in Combination With Nivolumab in Participants With Advanced Solid Tumors
100 Clinical Results associated with BMS-986449
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100 Translational Medicine associated with BMS-986449
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100 Patents (Medical) associated with BMS-986449
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100 Deals associated with BMS-986449
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
United States
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
06 Jun 2023
Advanced Malignant Solid NeoplasmPhase 2
France
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
06 Jun 2023
Advanced Malignant Solid NeoplasmPhase 2
Spain
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
06 Jun 2023
Advanced Malignant Solid NeoplasmPhase 2
Italy
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
06 Jun 2023
Advanced Malignant Solid NeoplasmPhase 2
Netherlands
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
06 Jun 2023
Advanced Malignant Solid NeoplasmPhase 2
Belgium
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
06 Jun 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Deal

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Clinical Trial

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Approval

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Regulation

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