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Last update 20 Mar 2025

Sulfamerazine

Last update 20 Mar 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

2-(4-Aminobenzenesulfonamido)-4-methylpyrimidine, 2-(Sulfanilamido)-4-methylpyrimidine, 2-(p-Aminobenzolsulfonamido)-4-methylpyrimidine

+ [9]

Target

bacterial DHPS

Action

inhibitors

Mechanism

bacterial DHPS inhibitors(Bacterial dihydropteroate synthase inhibitors)

Therapeutic Areas

Infectious Diseases

Active Indication

Bacterial Infections

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC11H12N4O2S

InChIKeyQPPBRPIAZZHUNT-UHFFFAOYSA-N

CAS Registry127-79-7

100 Clinical Results associated with Sulfamerazine

100 Translational Medicine associated with Sulfamerazine

100 Patents (Medical) associated with Sulfamerazine

4,694

Literatures (Medical) associated with Sulfamerazine

01 Jul 2025·Separation and Purification Technology

Hydroquinone enhanced Cu(II)/peroxymonosulfate for the degradation of sulfonamide antibiotics under acidic pH conditions

Author: Lv, Xiaoli ; Huang, Xianfeng ; Xiao, Jibo ; Cai, Anhong ; Wang, Tianhong ; Zhao, Min ; Zhang, Hui

The Cu(II)-mediated activation of peroxymonosulfate (PMS) has been studied for the degradation of contaminants due to its ability to produce reactive species.However, the yield of reactive species generated from Cu(II)/PMS is relatively low under acidic conditions due to the slow conversion rate of metal valence states, which limits its application prospects.Herein, we found that the introduction of hydroquinone (HQ) in the Cu(II)/PMS system can accelerate the activation of PMS by promoting the redox cycling of Cu(II)/Cu(I), thereby achieving efficient destruct of sulfonamide antibiotics.The degradation rate constants of six sulfonamide antibiotics by HQ/Cu(II)/PMS system was 5-8 times of that by Cu(II)/PMS system under pH 3.0.Both hydroxyl radical (HO.) and singlet oxygen (1O₂) participated in the degradation of sulfamethoxazole (SMX, a representative sulfonamide antibiotic), and the former played the most important role.HQ improved the reduction of Cu(II) to Cu(I) due to the electron-donating capacity of hydroxyl in HQ, thereby promoting PMS decomposition to produce more HO. under acidic conditions.The presence of humic acid (HA) and low concentration of Cl^- presented the inhibitory effect on SMX degradation, while the degradation of SMX was promoted in the presence of high concentration of Cl^-.The addition of NO₃^- and SO₄^2- has almost no effect on the removal of SMX.The degradation pathways of SMX by HQ/Cu(II)/PMS system mainly involved in the S-N cleavage and amino oxidationThe significant enhancement effects were still observed in actual wastewater treatment by Cu(II)/PMS system after introduction of HQ.

01 Apr 2025·Food Chemistry

Tetraphenylmethane based three-dimensional conjugated microporous polymer as adsorbent for solid-phase extraction of trace sulfonamide antibiotics in milk samples

Article

Author: Zhou, Xin ; Zang, Xiaohuan ; Chang, Qingyun ; Zhang, Shuaihua ; Wang, Chun ; Huang, Luan ; Wang, Zhi

Sulfonamide antibiotics have a broad spectrum of antibacterial action and are widely used, but their overuse poses a threat to human health. In this study, a three-dimensional conjugated microporous polymer, which was designated as TPM-CMP, was synthesized via Friedel-Crafts reaction by using tetraphenylmethane (TPM) and biphenyl dichlorobenzene as monomers, and it was utilized as an adsorbent in solid-phase extraction (SPE) of sulfonamides. The TPM-CMP demonstrated high extraction efficiency for sulfonamides due to π-stacking interactions, hydrophobic forces, and pore-filling effects. Consequently, the SPE was combined with liquid chromatography to detect sulfonamides in milk samples. For this method established in this study, a good linear response was observed in the range of 3.3-300.0 ng g^-1, with a detection limit (S/N = 3) between 1.0 and 1.5 ng g^-1. The method recoveries of four sulfonamide in milk samples ranged from 83.4 % to 117 %, with relative standard deviations below 10 %.

01 Apr 2025·Talanta

Rapid and enhanced detection of sulfonamide antibiotic using task-specific ionic liquids nanoconfined in tunable nanoporous carbons

Article

Author: Liu, Yuchi ; Zhang, Lei ; Liu, Zhuang ; Xu, Xu ; Guo, Yuhan

The development of a novel multifunctional adsorbent for the sensitive detection and capture of antibiotic residues in environmental and food samples presents a significant challenge. In this study, we synthesized a pioneering nanocomposite, ILs@PC, by encapsulating task-specific ionic liquids (ILs) within nitrogen-doped porous carbon (PC) derived from metal-triazolate frameworks. This ILs@PC nanocomposite functions as a multifunctional adsorbent in dispersive solid-phase extraction (DSPE), enabling simultaneous sorptive removal, sensitive detection, and molecular sieve selection. The ILs@PC demonstrated enhanced adsorption efficiency and sensitivity for sulfonamide antibiotics (SAs) compared to the pristine PC, attributed to the nanoconfinement effect of the ILs and the influence of pore volume on this effect. When integrated with high-performance liquid chromatography (HPLC), the ILs@PC-based DSPE method achieved a detection limit of 0.75-1.88 μg L^-1 for SAs, along with satisfactory recoveries of 86.0 %-111.9 %. Additionally, a portable syringe device was developed to facilitate rapid on-site extraction and enrichment of SAs. The practicality of this method was validated through its successful application in detecting SAs in real samples, including lake water and milk. This approach highlights its potential for efficient and rapid monitoring of antibiotic residues in both environmental and food systems.

100 Deals associated with Sulfamerazine

External Link

KEGG	Wiki	ATC	Drug Bank
D02435	Sulfamerazine	D06BA06 J01ED07	DB01581

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Bacterial Infections	-	-	-

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