BACKGROUNDMeticillin-resistant Staphylococcus aureus (MRSA) is a common causative agent of serious healthcare-related infections in neonatal intensive care units (NICUs). In adult ICUs, pulsed-xenon ultraviolet (PX-UV) disinfection of environmental surfaces, along with alcohol-based hand hygiene and terminal cleaning, has been demonstrated to reduce the MRSA acquisition rate.AIMTo explore the impact of PX-UV use in NICUs on reducing MRSA transmission.METHODSThe incidence of newly detected MRSA cases was recorded for all patients between January 2021 and December 2022. UV irradiation was used in addition to terminal manual cleaning. During the baseline period, irradiation was performed on areas following the use by patients with MRSA; in the intervention period, irradiation was performed after each patient's use.FINDINGSThough there was no observed change in the frequency of hand hygiene compliance throughout the study period, the total number of MRSA cases detected per 1000 patient-days decreased significantly.CONCLUSIONIn NICUs, UV irradiation of environmental surfaces, in addition to hand hygiene practices and conventional environmental maintenance, may be effective in reducing MRSA infection.

01 May 2024·Infection Control & Hospital Epidemiology

The impact of environmental cleaning protocol featuring PX-UV in reducing the incidence of multidrug-resistant gram-negative healthcare-associated infection and colonization in intensive care units in Thailand

Article

Author: Apisarnthanarak, Piyaporn ; Weber, David J ; Jantarathaneewat, Kittiya ; Apisarnthanarak, Anucha ; Vaivoothpinyo, Supavit ; Rutjanawech, Sasinuch ; Sathitakorn, Ornnicha ; Tantiyavarong, Pichaya

AbstractIn this quasi-experimental study, implementing PX-UV to the standard environmental cleaning protocol was associated with a reduction in the overall incidence of multidrug-resistant (MDR) gram-negative organisms (P = .01) and MDR Acinetobacter baumannii (P = .001) in intervention intensive care units. However, the intervention did not reduce patient length of stay and 30-day mortality.

01 May 2022·MycosesQ2 · MEDICINE

Fluconazole versus micafungin for initial antifungal prophylaxis against Candida in pancreas transplant recipients: A comparative study of two consecutive periods

Q2 · MEDICINE

Article

Author: González, Esther ; Herrero‐Martínez, Juan María ; San Juan, Rafael ; Rodríguez‐Goncer, Isabel ; Aguado, José María ; Andrés, Amado ; Fernández‐Ruiz, Mario ; López‐Medrano, Francisco ; Alonso‐Carrillo, Jesús ; Muñoz de la Espada, María ; Justo, Iago ; Lumbreras, Carlos ; Manrique, Alejandro ; Jiménez, Carlos ; Marcacuzco, Alberto ; Loinaz, Carmelo ; Pérez‐Jacoiste Asín, María Asunción

AbstractBackgroundInvasive fungal infection, particularly intraabdominal candidiasis, exerts a negative impact on the outcome of pancreas transplant recipients (PTRs). Optimal antifungal prophylaxis in this context remains unclear.MethodsWe performed a single‐centre retrospective study to compare the incidence of invasive candidiasis during the first 6 post‐transplant months in a cohort of 218 PTRs over two periods in which different agents for antifungal prophylaxis were used: fluconazole (Fluco‐Px) from March 1995 to June 2012, and micafungin followed by fluconazole (Mica‐Px) from July 2012 to December 2018.ResultsA total of 152 and 66 PTRs received Fluco‐Px and Mica‐Px. Mean age was 39.7 ± 7.8 years, 56.4% (123/218) were males, and 85.3% (186/218) underwent simultaneous pancreas–kidney transplantation. Invasive candidiasis occurred in 21.7% (33/152) of PTRs under Fluco‐Px compared to 24.2% (16/66) of those under Mica‐Px (p‐value = .681). Median time from transplantation to infection was 8 days (interquartile range [IQR]: 6–16) under Fluco‐Px versus 6.5 (IQR: 3.3–15.8) under Mica‐Px (p‐value = .623). Non‐albicans Candida species comprised 27.5% (11/40) and 25.0% (4/16) of episodes under Fluco‐Px and Mica‐Px respectively (p‐value = .849). Surgical site infection was the most common form in both groups (82.5% [33/40] and 87.5% [14/16]; p‐value = .954). Multivariable analysis identified cold ischaemia time of the pancreas and kidney grafts, surgical reintervention and insulin requirement after transplantation as risks factor for invasive candidiasis.ConclusionThis retrospective study did not reveal a significant benefit from the initial use of micafungin‐based antifungal prophylaxis over fluconazole among PTRs in terms of invasive candidiasis.

100 Deals associated with GENO-2

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Herpes Simplex	Preclinical	US	Genocea Biosciences, Inc.	-

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis


No Data

GENO-2

Overview

Basic Info

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation