Delving into the Latest Updates on Doxecitine with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

2'-deoxycytidine

Target-

Action-

Mechanism-

Therapeutic Areas

Congenital Disorders

Active Indication

Thymidine kinase 2 deficiency

Inactive Indication-

Originator Organization

Zogenix, Inc.

Active Organization

UCB Biosciences, Inc.

Inactive Organization-

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

Login to view timeline

Structure/Sequence

Molecular FormulaC9H13N3O4

InChIKeyCKTSBUTUHBMZGZ-SHYZEUOFSA-N

CAS Registry951-77-9

This Expanded Access Record for doxecitine and doxribtimine includes the following managed access programs:
TK0113: Data Collection for Patients in the Company Supported Expanded Access Program Expanded Access Status: Available
TK0115: TREATMENT PROTOCOL FOR DOXECITINE AND DOXRIBTIMINE - Company-sponsored Intermediate-size Cohort Expanded Access Program for Doxecitine and Doxribtimine for Patients with Thymidine Kinase 2 Deficiency (TK2d) with an Age of Symptom Onset ≤ 12 Years Expanded Access Status: Available

Start Date-

Sponsor / Collaborator

UCB Biosciences, Inc.

CTIS2024-510763-35-00

/ Not yet recruitingPhase 2

An Off-Label Single Arm Clinical Study to Evaluate the Efficacy and Safety of doxecitine and doxribtimine in Adult Subjects with Thymidine Kinase 2 (TK2) Deficiency

Start Date-

Sponsor / Collaborator

Hospital Universitário

NCT03845712

/ Active, not recruitingPhase 2

A Phase 2 Open-Label Study of Continuation Treatment With Combination Pyrimidine Nucleosides in Patients With Thymidine Kinase 2 Deficiency (TK2)

This is a Phase 2 prospective open-label treatment study of the safety and efficacy of doxecitine and doxribtimine in study participants with thymidine kinase 2 (TK2) deficiency who participated in the retrospective study MT-1621-101 [NCT03701568] or who were receiving nucleos(t)ide treatment and were approved by the Sponsor.

Start Date05 Jul 2019

Sponsor / Collaborator

UCB Biosciences, Inc.

100 Clinical Results associated with Doxecitine

Login to view more data

100 Translational Medicine associated with Doxecitine

Login to view more data

100 Patents (Medical) associated with Doxecitine

Login to view more data

3,726

Literatures (Medical) associated with Doxecitine

01 Apr 2025·Agriculture, Ecosystems & Environment

Long term intercropping promotes improvement of soil quality and alleviates faba bean wilt disease

Author: Hu, Bijie ; Zhang, Jing ; Wang, Binzhi ; Dong, Kun ; Zheng, Yiran ; Dong, Yan ; Zhang, Zhengyu

Intercropping is vital for enhancing soil quality improvement and improving ecol. services.This study integrated the anal. of rhizosphere metabolites and microbial communities to elucidate the mechanism by which the long-term intercropping could regulate the soil rhizosphere microecol. and promote the faba bean growth.Two planting modes, faba bean single cropping and faba bean-wheat intercropping, along with the planting durations of 1 and 9 years, were established to investigate the wilt disease occurrence.The growth indicators, the soil phys. and chem. properties, the rhizosphere microbial communities, and the changes in rhizosphere metabolites of faba bean were measured.Continuous cropping can lead to poor soil conditions and high incidence of faba bean disease, while intercropping can alleviate the occurrence of diseases.Compared with monoculture for 1 yr, monoculture for 9 yr can promote the growth of faba bean by 12.89-29.19 %, reduce the incidence rate of fusarium wilt by 41.38 %, increase the proportion of large aggregates with R> 0.25 mm by 18.87 % by reducing the soil bulk d. by 6.67 %, average weight diameter 23.16 %, geometric mean diameter 26.51 %, maintaining soil pH stability and increasing soil organic matter by 30.74 % can improve soil structure, and the disease control effect is more significant.It is also possible to reduce the relative abundance of Fusarium by 8.93 % by improving the soil microbial community structure.In addition, metabolomics anal. also showed that long-term intercropping promotes the secretion of flavonoids and terpenoids in the rhizosphere soil of faba bean, enhancing their resistance.Through correlation anal., it was found that soil microbial activity is closely related to key metabolites in crop rhizosphere.The secretion and synthesis of flavonoids and terpenes can reduce the abundance of faba bean pathogens and alleviate their disease occurrence.The faba bean-wheat long-term intercropping improved the soil phys. and chem. properties, reconstructed the microbial community structure, and reduced the pathogenic bacteria abundance through rhizosphere metabolites, thereby maintaining soil quality improvement and promoting healthy faba bean growth.

01 Apr 2025·Food Chemistry

Non-targeted and targeted detection of hydrophilic compounds in fu brick tea: A study on samples from major Chinese production regions and different processing stages

Article

Author: Huang, Jianan ; Xu, Junren ; Yuan, Yong ; Yin, Feiyan ; Zhao, Mengmeng ; Li, Na ; Liu, Zhonghua ; Zhu, Mingzhi ; Zhao, Yiqiao ; Wang, Kunbo ; Chao, Jin

Systematic research is still lacking on the content of hydrophilic compounds in Fu Brick Tea (FBT) from major Chinese production regions and their variation patterns during the processing of FBT. This study utilized optimized non-targeted (UHPLC-Q-Exactive Orbitrap-MS) and targeted (UHPLC-QqQ-MS) metabolomics to analyze 73 FBT samples from six regions of China and 30 samples from different stages of FBT processing. 573 and 74 hydrophilic compounds were respectively relatively and absolutely quantified for the first time. Among the 73 FBT samples, alkaloids were the most abundant (26221.76-36701.75 mg/kg), followed by soluble sugars (211372.59-26112.85 mg/kg), organic acids (17014.07-23589.20 mg/kg), amino acids (6664.59-9791.46 mg/kg), nucleotides (1020.33-2175.16 mg/kg), and nucleoside (650.86-1446.26 mg/kg). During the processing of FBT, sugars, acids, nucleotides, and nucleosides increased, while amino acids decreased, and alkaloids slightly increased. This study enhances the understanding of hydrophilic compounds in FBT.

05 Mar 2025·Journal of the American Chemical Society

Unraveling Hydration Shell Dynamics and Viscosity Effects Around Cyanamide Probes via 2D IR Spectroscopy

Article

Author: Familo, Savannah B. ; Osofsky, Ellia H. ; Mallon, Christopher J. ; Hassani, Majid ; Fenlon, Edward E. ; Tucker, Matthew J.

Hydration dynamics and solvent viscosity play critical roles in the structure and function of biomolecules. An overwhelming body of evidence suggests that protein and membrane fluctuations are closely linked to solvent fluctuations. While extensive research exists on the use of vibrational probes to detect local interactions and solvent dynamics, fewer studies have explored how the behavior of these reporters changes in response to bulk viscosity. To address this gap, two-dimensional infrared spectroscopy (2D IR) was employed in this study to investigate the ultrafast hydration dynamics around a cyanamide (NCN) probe attached to a nucleoside, deoxycytidine, in aqueous solutions with varying glycerol content. The use of a small vibrational probe on a targeted nucleic acid offers the potential to capture more localized hydration dynamics than alternative methods. The time scales for the frequency correlation decays were found to increase linearly with bulk viscosity, ranging from 0.9 to 11.4 ps over viscosities of 0.96-49.1 cP. Additionally, molecular dynamics (MD) simulations were performed to model the local hydration dynamics around the NCN probe. Interestingly, increasing the glycerol content did not significantly alter the hydration of the deoxycytidine. The MD simulations further suggested that the NCN probe's frequency fluctuations were primarily influenced by the dynamics of water in the second solvation shell. Cage correlation functions, which measure the movement of water molecules in and out of the second solvation shell, exhibited decays that closely matched those of the frequency-fluctuation correlation function (FFCF). These findings offer new insights into hydration dynamics and the impact of viscosity on biological systems.

100 Deals associated with Doxecitine

Login to view more data

R&D Status

10 top R&D records.

Login

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Thymidine kinase 2 deficiency	Phase 2	Spain	UCB Biosciences, Inc.	05 Jul 2019
Thymidine kinase 2 deficiency	Phase 2	Israel	UCB Biosciences, Inc.	05 Jul 2019
Thymidine kinase 2 deficiency	Phase 2	United States	UCB Biosciences, Inc.	05 Jul 2019