A Phase IIIb/IV, Multi-centre, Double-blind, Randomised, Placebo-controlled Parallel Group Study to Compare the Efficacy and Safety of Movicol® With Placebo in Patients With Constipation Associated With Irritable Bowel Syndrome (IBS)

Multi-centre, double-blind, randomised, placebo-controlled, parallel group study.

Start Date01 Nov 2008

Sponsor / Collaborator

Norgine Ltd.

100 Clinical Results associated with Polyethylene glycol 3350/Potassium chloride/Sodium bicarbonate/Sodium chloride

100 Translational Medicine associated with Polyethylene glycol 3350/Potassium chloride/Sodium bicarbonate/Sodium chloride

100 Patents (Medical) associated with Polyethylene glycol 3350/Potassium chloride/Sodium bicarbonate/Sodium chloride

Literatures (Medical) associated with Polyethylene glycol 3350/Potassium chloride/Sodium bicarbonate/Sodium chloride

01 Dec 2022·3D Printing and Additive Manufacturing

Consumer Assessment of 3D-Printed Food Shape, Taste, and Fidelity Using Chocolate and Marzipan Materials

Article

Author: Binks, Martin ; Hartmann, Christina ; Siegrist, Michael ; Chirico Scheele, Stefania ; Egan, Paul F.

Additive manufacturing enables the production of complex structures with emerging approaches showing great promise in the food industry for design customization. Three-dimensional food printing has benefits for providing personalized health and shape fabrication for consumers. Past studies have demonstrated positive consumer perceptions for 3D food printing, but there is still a need for consumer validation of the technology through consumption and rating of fabricated 3D-printed foods. This article measures consumer response on shape, taste, and fidelity for 3D-printed food designs. Participants (N = 28) were presented with a series of designs differing in shape complexity and ingredients (marzipan and chocolate) and provided ratings using a visual analog scale (100 mm line). The results show that fabricated shapes with higher complexity were preferred by participants with 8.8 ± 0.3 ratings over lower complexity shapes with 5.5 ± 0.4 ratings. Taste preference was primarily dependent on the material selection, with chocolate material preferred by participants with 8.2 ± 0.5 ratings over marzipan material with 6.0 ± 0.5. Results demonstrated that participants preferred 3D-printed shapes that achieved high fidelity in recreating their computer-aided design (CAD) with 7.3 ± 0.3 ratings that were greater than 5.5 ± 0.5 for low-fidelity prints. These findings demonstrate first measurements of 3D food printing from a consumer perspective and provide a foundation for future studies on personalized manufacturing and nutrition.

01 Jun 2021·Digestive Diseases and SciencesQ3 · MEDICINE

Comparative Effectiveness of Commercial Bowel Preparations in Ambulatory Patients Presenting for Screening or Surveillance Colonoscopy

Q3 · MEDICINE

Article

Author: Gupta, Niyati ; Garber, Ari ; Burke, Carol A ; Rothberg, Michael B ; Rizk, Maged ; Sarvepalli, Shashank ; Morris-Stiff, Gareth ; McMichael, John ; Vargo, John ; Ibrahim, Mounir ; Bhatt, Amit

BACKGROUNDInadequate bowel preparation (IBP) is associated with reduced adenoma detection. However, limited research has examined the impact of different commercial bowel preparations (CBPs) on IBP and adenoma detection. We aim to determine whether type of CBP used is associated with IBP or adenoma detection.METHODSWe retrospectively evaluated outpatient, screening or surveillance colonoscopies performed in the Cleveland Clinic health system between January 2011 and June 2017. IBP was defined by the Aronchick scale. Multilevel mixed-effects logistic regression was performed to assess the association between CBP type and IBP and adenoma detection. Fixed effects were defined as demographics, comorbidities, medication use, and colonoscopy factors. Random effect of individual endoscopist was considered.RESULTSOf 153,639 colonoscopies, 75,874 records met inclusion criteria. Median age was 54; 50% were female; 17.7% had IBP, and adenoma detection rate was 32.6%. In adjusted analyses, compared to GoLYTELY, only NuLYTELY [OR 0.66 (95% CI 0.60, 0.72)] and SuPREP [OR 0.53 (95% CI 0.40, 0.69)] were associated with reduced IBP. Adenoma detection did not vary based on the type of bowel preparation used.CONCLUSIONSAmong patients referred for screening or surveillance colonoscopy, choice of CBP was not associated with adenoma detection. Decisions about CBP should be based on other factors, such as tolerability, cost, or safety.

01 Apr 2020·Telemedicine and e-HealthQ3 · MEDICINE

A Digital Preprocedure Instruction Program for Outpatient Colonoscopy

Q3 · MEDICINE

Article

Author: Richter, James M. ; Pandolfi, Michael C. ; Campbell, Emily J. ; Ha, Jasmine B. ; Marx, Madeline

Introduction:Many patients struggle with colonoscopy preparation, which is complex and can be an uncomfortable as well as a time-consuming process. The confusion and anxiety from the preprocedure process may lead patients to delay their colonoscopy or skip it altogether. Digital health technology that focuses on patient engagement can play an important role in promoting colorectal cancer screening.Methods:A digital preprocedure instruction program was implemented for outpatient colonoscopy by sending critical reminders and instructions to patients through a series of short message service messages and/or emails. Eligible patients included English speakers on GoLYTELY^®/NuLYTELY^® or MiraLAX^® preparation regimens with a valid cellphone or email address in the electronic health record. We examined the impact of digital instructions on bowel preparation quality, no-show and same-day cancellations over a 3-month period between an intervention group of 756 patients and a control group of 2,103 patients. Patients who enrolled in the digital instructions also received a patient satisfaction survey.Results:Our controlled study demonstrated the effectiveness of digital instructions to reduce no-show and same-day cancellation rates for outpatient colonoscopy from 10.40% to 6.08% (p < 0.001). Bowel preparation quality was not significantly different between the two groups (p = 0.23). However, 90% of patients who enrolled in the program rated their satisfaction with the digital reminders very highly.Discussion:A digital preprocedure instruction program can have a positive impact on operational efficiency, quality of care, and patient satisfaction. This study shows how digital health tools can effectively engage patients scheduled for a colonoscopy, increase appointment adherence, and, therefore, lead to better cancer screening.

100 Deals associated with Polyethylene glycol 3350/Potassium chloride/Sodium bicarbonate/Sodium chloride

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Chronic constipation	New Zealand	Norgine Ltd.	03 Dec 1998
Intestinal preparation	United States	Braintree Laboratories, Inc.	22 Apr 1991

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Constipation	Discovery	Germany	Norgine Ltd.	01 Nov 2008
Constipation	Discovery	Sweden	Norgine Ltd.	01 Nov 2008
Constipation	Discovery	Czechia	Norgine Ltd.	01 Nov 2008
Constipation	Discovery	France	Norgine Ltd.	01 Nov 2008
Constipation	Discovery	Poland	Norgine Ltd.	01 Nov 2008
Constipation	Discovery	Italy	Norgine Ltd.	01 Nov 2008

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