Acridine carboxamide

This study applies a social foreground perspective to assess whether the Deferred Action for Childhood Arrivals (DACA) program impacted the self‐rated health of coresident parents of DACA‐eligible individuals.

DACA status grants a temporary work permit and allows for a stay of deportation for undocumented persons who entered the United States as children. Although research points to the positive health benefits of DACA for its recipients, less is known about whether the program affects the health of family members, including parents.

This study uses data from the National Health Interview Study (2008–2015) on foreign‐born adults and their coresident parents. We applied a difference‐in‐differences design to examine whether the self‐rated health of coresident mothers and fathers changed following the passage of DACA for DACA‐eligible individuals.

In contrast to expectations, DACA was associated with worse self‐rated health among coresident, partnered parents. These results may be because DACA also decreased the likelihood of coresiding with parents and changed the composition of coresident parents themselves. Following DACA, fewer eligible offspring lived with parents overall, but among those that did, parents tended to be older and less healthy.

Findings underscore how DACA may be used as a resource to support older parents experiencing health challenges, in particular among older undocumented immigrants, who make up a growing share of the undocumented population in the United States.

Oral Cancer is one of the major killers in India and of global concern.An attempt has been made here to identify small mol. inhibitors of Bcl-2 (B-cell lymphoma 2) protein through docking studies in search of new oral cancer drugs from a curated set of 276 known anti-neoplastic agents obtained from PubChem.The Bcl-2 protein (PDB id:6QGH), being complexed with ligand ABT-263, has been detached from the complex.The ligand-free protein and 276 compounds have been prepared for docking studies using corresponding tools available in Discovery Studio (DS), ver.4.1.The 276 compounds have been docked on the first site of the protein using LibDock docking program available in DS.By considering Methotrexate as the reference compound (LibDock score: 114.76), we have identified 25 compounds as the most potential oral cancer drugs having LibDock scores greater than 100.Another set of 114 compounds with LibDock scores between 80 and 100 have also been identified as the next set of potential drug candidates and some of them show anti-apoptosis properties.Two other compounds with LibDock scores below 80 have been identified for comparative analyses with some high-scoring compoundsThe docking results have been given in tables and pictures (screenshots) of the docked poses of selected compounds have been shown to illustrate the findings.Finally, the most suitable potential compounds have been identified by applying Lipinski′s Rule of 5.The present approach using known anti-neoplastic agents is believed to help discover potential anti-oral cancer drug candidates.