Effect of sulphadoxine-pyrimethamine co-administration on pharmacokinetics of alpha beta arteether, an anti-malarial agent, in healthy male volunteers

Start Date26 Jul 2011

Sponsor / Collaborator-

100 Clinical Results associated with Arteether

100 Translational Medicine associated with Arteether

100 Patents (Medical) associated with Arteether

477

Literatures (Medical) associated with Arteether

27 Feb 2025·Current Topics in Medicinal Chemistry

A Comprehensive Review on the Antimicrobial Activity of the Genus Artemisia, Artemisinin, and its Derivatives

Article

Author: Sharma, Kiran

Abstract:Artemisinin and its semisynthetic derivatives are a group of bioactive chemicals obtained mostly from the extracts of Artemisia species that exert a significant amount of antimalarial activity while remaining relatively safe and tolerable. However, their effectiveness is not limited to malaria; it extends to a variety of human infectious diseases. Mostly the mode of action includes the generation of free radicals by breaking the endoperoxide link in its molecular structure, which facilitates the eradication of microbial species. Artemisinins are found to inhibit bacterial, viral, protozoal, helminth, and fungal infections. Their derivatives, like artemisone, a reversible inhibitor, target the viral replication cycle, and artesunate suppresses EBV infection by inhibiting the production of early EBV proteins. They were also found to be highly effective against Helicobacter pylori and Mycobacterium tuberculosis by generating peroxides in a time and concentrationdependent way. Other derivatives, such as artesunate, artemether, and arteether, have also shown antimicrobial activity that can be administered orally, rectally, intramuscularly, or intravenously. This review aims to provide a complete update on the antimicrobial applications of Artemisinin and its semi-synthetic derivatives, as well as derived dimers/trimers. The paper reflects a significant potential for the discovery of novel Artemisinin medications that can be used as supplementary treatments for various diseases. However, further translational and experimental research is required for optimization and the establishment of pharmacokinetic profiles. In addition, health authorities are also required to regulate the present Artemisinins and newly discovered derivatives to ensure their long-term effectiveness in the worldwide fight against antibiotic resistance.

01 Sep 2024·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Research progress on artemisinin and its derivatives in treatment of orthopedics-related diseases].

Review

Author: Feng, Xiao-Tian ; Yang, Pei-Chuan ; Sun, Ya-di ; Shen, Jia-Hui ; Li, Guang ; Li, Yan ; Ma, Xin-Long ; Dong, Ben-Chao ; Wang, Yan ; Zhou, Li-Yun ; Cui, Hong-Wei ; Li, Yi-Yang ; Wang, Qi-Yu ; Ma, Jian-Xiong ; Ma, Tian-Cheng

As research into the mechanisms of orthopedic diseases continues to deepen, the shortcomings of traditional single-target the-rapies are becoming increasingly apparent. Consequently, the search for multi-target drugs has become the mainstream research direction for orthopedics-related diseases. Artemisinin, a sesquiterpene lactone compound extracted from Artemisia annua, has led to the gradual synthesis of various derivatives such as dihydroartemisinin, artesunate, artemether, and arteether. Recent pharmacological studies have found that artemisinin and its derivatives can treat osteoporosis, osteoarthritis, rheumatoid arthritis, osteosarcoma, and other orthopedic diseases by regulating osteoblast-osteoclast coupling, modulating immune response, inhibiting angiogenesis, protecting cartilage, and inhibiting tumor growth. This paper reviewed the metabolic characteristics and mechanisms of action of artemisinin and its derivatives in the treatment of orthopedic diseases, aiming to inspire modern research on artemisinin-based drugs and orthopedic diseases.

01 Sep 2024·South African Journal of Botany

LC HRMS-based metabolomics on Acalypha indica with different altitude and antioxidant activity

Author: Sabarudin, Akhmad ; Aulanni′am ; Hayati, Elok Kamilah ; Aulanni'am ; Karomah, Alfi Hudatul ; Rafi, Mohamad

Achalypha indica is a weed that has medicinal properties.This study aims to determine the metabolite profile and evaluate the antioxidant activity of A. indica from areas with different altitudes, Tuban (20 to 50 masl; TBN), Banyuwangi (60 to 90 masl; BB), Magetan (300 to 600 masl; MGT), and Malang (500 to 800 masl; MLG).The ethanol extract of A. indica was analyzed for total phenolics and antioxidant activity.Separation and identification of samples were carried out using liquid chromatog.-high-resolution mass spectrometry (LC-HRMS), then classified by Principal Component Anal. (PCA).The total phenol value ranged from 6.83 to 10.67 mg GAE /g of dry powder, with an antioxidant IC50 of 86.09 to 118.96 μg/mL.LC-HRMS successfully identified 83 metabolites.PCA anal. was able to clearly distinguish each sample based on the altitude of the growing location with a total variance value reaching 82 % (PC-1: 57 %, and PC-2: 25 %).Heat map anal. that observes variations in metabolite composition in each sample shows an increase in the content of flavonoid compounds in the lowlands under certain geog. conditions.Therefore, the height of the growing location has a significant influence on the metabolite profile and antioxidant activity.These findings are very important for assessing the quality, safety, and efficacy of medicinal plant raw materials.

100 Deals associated with Arteether

External Link

KEGG	Wiki	ATC	Drug Bank
D07361	Arteether	P01BE04	DB13851

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Malaria, Falciparum	Nigeria	-	-
Malaria, Falciparum	Niger	-	-
Malaria, Falciparum	Thailand	-	-
Malaria, Falciparum	Myanmar (Burma)	-	-
Malaria, Falciparum	Pakistan	-	-
Malaria, Falciparum	Sudan	-	-
Malaria, Falciparum	France	-	-

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Toxoplasmosis	Discovery	United States	-	-

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis