Last update 21 Nov 2024
SH-3765
Last update 21 Nov 2024
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms |
Target |
Mechanism PRMT5 inhibitors(Protein arginine methyltransferase 5 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 1 |
First Approval Date- |
Regulation- |
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Related
2
Clinical Trials associated with SH-3765SH3765片在晚期恶性肿瘤患者中单、多次剂量递增的安全性、耐受性及药代动力学的I期临床研究。
[Translation] A phase I clinical study on the safety, tolerability and pharmacokinetics of single and multiple ascending doses of SH3765 tablets in patients with advanced malignant tumors.
A Phase I, Open-Label Study to Determine Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Efficacy of SH3765 Tablet in Patients With Advanced Malignant Tumor
100 Clinical Results associated with SH-3765
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100 Translational Medicine associated with SH-3765
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100 Patents (Medical) associated with SH-3765
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1
Literatures (Medical) associated with SH-376501 Jun 2024Cancer Letters
PRMT5 activates lipid metabolic reprogramming via MYC contributing to the growth and survival of mantle cell lymphoma
Article
Author: Gao, Rui ; Li, Yue ; Wang, Li ; Shen, Hao-Rui ; Li, Jian-Yong ; Duan, Zi-Wen ; Du, Kai-Xin ; Wu, Jia-Zhu ; Wang, Wei-Ting ; Wang, Rong ; Xu, Wei ; Liang, Jin-Hua ; Guo, Jin-Ran ; Yin, Hua ; Zhang, Xin-Yu
100 Deals associated with SH-3765
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R&D Status
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Advanced cancer | Phase 1 | CN | 24 Aug 2021 | |
| Non-Hodgkin Lymphoma | Phase 1 | CN | 24 Aug 2021 | |
| Solid tumor | Phase 1 | CN | 24 Aug 2021 | |
| Neoplasms | Discovery | CN | 24 Aug 2021 |
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