Delving into the Latest Updates on CB-PIC with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

(E)-4-((2-(3-oxopop-1-enyl)phenoxy)methyl)pyridinium malonic acid

Target

Akt x STAT3 x p38 MAPK

Mechanism

Akt inhibitors(Proto-oncogene proteins c-akt inhibitors), STAT3 inhibitors(Signal transducer and activator of transcription 3 inhibitors), p38 MAPK inhibitors(P38 mitogen-activated protein kinase inhibitors)

Therapeutic Areas

Neoplasms

Active Indication

Neoplasms

Inactive Indication-

Originator Organization

Kyung Hee University

Active Organization

Kyung Hee University

Inactive Organization-

Drug Highest PhaseDiscovery

First Approval Date-

Regulation-

The purpose of the study was to assess effects of the competitive N-methyl-D-aspartate (NMDA) receptor antagonist D-(E)-4-(3-phosphonoprop-2-enyl)piperazine-2-carboxylic acid (D-CPPene) upon focal cerebral infarction and brain oedema in the rat. Focal cerebral ischaemia was produced by permanent occlusion of the middle cerebral artery under halothane anaesthesia. The anaesthetic gas was discontinued immediately after the occlusion and the rats were killed 24 hours later. Cerebral infarction and brain swelling were each assessed on the frozen brain sections at 8 predetermined coronal planes. Pretreatment with D-CPPene (4.5 mg/kg i.v. followed by continuous infusion at 3 mg/kg/h until sacrifice) 15 minutes prior to MCA occlusion, significantly reduced the volume of infarction in the cerebral hemisphere by 29% (p < 0.05). Brain swelling, obtained by subtracting the nonischaemic hemispheric volume from the ischaemic hemispheric volume, was significantly reduced with D-CPPene treatment and the mean reduction in swelling (34% less than the controls: p < 0.001) proportionately similar to the decrease in infarct volume in the same animals. These data indicate that systemic administration of the competitive NMDA receptor antagonist D-CPPene has neuroprotective effects against ischaemic brain damage, and the reduction in brain swelling occurs in parallel with the reduction in ischaemic damage.

100 Deals associated with CB-PIC

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