A 57-year-old black male patient was admitted with flatulence and post-prandial fullness a month ago. No other gastrointestinal complaints. He had history of arterial hypertension, medicated with nifedipine 30mg/day and hydrochlorthiazide 50mg/day, and had been diagnosed and treated for malaria a week before admission. The patient reported frequent bathing in rivers and smoking habits since the age of 18, around a pack and a half a day. Abdominal ultrasound showed periportal fibrosis, without findings of portal hypertension. A rectal biopsy was performed with findings of Schistosome mansoni eggs on microscopy. This case illustrates a patient who was admitted due to dyspeptic syndrome, and during the study of his condition was found to have periportal fibrosis, which in a country endemic for Schistosomiasis such as Mozambique, this pathology must always be investigated. A history of bathing in rivers increases the chances of it being Schistosomiasis, confirmed by the demonstration of parasite eggs in a rectal biopsy. Treatment with prazinquantel was done at a dose of 40 mg/kg and outpatient follow-up was scheduled for six months.

01 Jul 2020·Pakistan journal of pharmaceutical sciences

Phytochemical analysis and reappraisal of diuretic activity of Delphinium brunonianum Royle and its mode of action in experimental rats.

Article

Author: Alharbi, Khalid Saad ; Ahmad, Muhammad Ishfaq ; Asif, Hira ; Bukhari, Syed Nasir Abbas ; Locatelli, Marcello ; Saleem, Hammad ; Alotaibi, Nasser Hadal ; Alamgeer, -

The aim of this study was the evaluation of diuretic potential of Delphinium brunonianum. Acute diuretic effect in rats was evaluated 8 h after administration of various doses of crude extract, fractions and hydrochlorthiazide. While, prolonged effect of butanolic fraction was assessed after 7days of oral administration in rats. Thereafter, involvement of different pathways in diuretic activity was also appraised. Furthermore, polyphenolic contents in butanolic fraction were assessed using HPLC/UV-VIS technique. All doses of extract and fractions induced a prominent increase in urine and Na⁺ excretion with no effect on excretion of K⁺. Prior administration of indomethacin and atropine considerably avoided the diuretic effect of butanolic fraction. Regarding the quantitative chemical analysis the polyphenolic contents were recorded as 28.78 µg/mg. Thus results of present investigation suggested that Delphinium brunonianum possess remarkable diuretic potential.

01 Dec 2019·Journal of HypertensionQ2 · MEDICINE

The association of smoothness index of central blood pressure with ambulatory carotid femoral pulse wave velocity after 20-week treatment with losartan in combination with amlodipine versus hydrochlorothiazide

Q2 · MEDICINE

Article

Author: Park, Sungha ; Choi, Dong-Ju ; Ahn, Young Keun ; Park, Chang Gyu ; Shin, Jinho ; Cho, Eun Joo ; Hong, Soon-Jun ; Lee, Hae Young ; Sung, Ki Chul ; Chae, Shung Chull ; Kim, Chong-Jin ; Kim, Young Jo ; Yoo, Byung Su ; Cho, Myeong-Chan ; Ha, Jong Won ; Kim, Soon Kil ; Youn, Ho Joong ; Hong, Taek Jong ; Chung, Wook Jin ; Sohn, Il-Suk

OBJECTIVESThe aim of this study was to identify associations between the smoothness index of central SBP (CSBP) and changes of ambulatory carotid femoral pulse wave velocity in response to 20-week treatments with losartan and amlodipine vs. losartan and hydrochlorthiazide combinations.METHODSFor 142 (losartan and hydrochlorthiazide: 72, losartan and hydrochlorthiazide: 70) patients examined with ambulatory central blood pressure (BP) monitoring device, we calculated smoothness indices and trough-to-peak ratios of brachial SBP, CSBP, ambulatory pulse pressure amplification (APPA), ambulatory augmentation index at heart rate 75 beats per minute (AAIx75) and ambulatory carotid femoral pulse wave velocity (AcfPWV).RESULTSMean age was 58.9 ± 12.3 years, and women accounted for 25.9%. Changes in office SBP/DBP were not different between groups (losartan and hydrochlorthiazide: -15.2 ± 15.0/-7.8 ± 8.0 vs. losartan and amlodipine: -14.9 ± 13.7/-9.2 ± 7.5 mmHg). Reduction of 24-h CSBP was not significantly different (losartan and hydrochlorthiazide: 6.4 ± 1.1 vs. losartan and amlodipine: 9.2 ± 1.1 mmHg, P = 0.074). Reduction in nocturnal AcfPWV was greater in the losartan and amlodipine group (losartan and hydrochlorthiazide: 0.09 ± 0.05 vs. losartan and amlodipine: 0.26 ± 0.05 m/s, P = 0.0216). Intraindividual SIs for CSBP were higher in the losartan and amlodipine group (0.40 ± 0.57 vs. 0.65 ± 0.74, P = 0.022). In multivariable regression analysis, smoothness index of CSBP was independently associated with the losartan and amlodipine group. In model additionally considering the changes in arterial stiffness, decrease in AcfPWV instead of the treatment group was independently associated with smoothness indices. In mediation analysis, smoothness index was fully mediated by reduction in night-time AcfPWV.CONCLUSIONLosartan and amlodipine combination was superior to the losartan and hydrochlorthiazide combination in terms of achieving higher smoothness index for CSBP after 20-week treatments. The effect of losartan and amlodipine on smoothness index was fully mediated by reduction of night-time AcfPWV.

100 Deals associated with Hydroflumethiazide/Reserpine

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KEGG	Wiki	ATC	Drug Bank
-	-	C02AA52 C02LA01 C03AH02	-

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Indication	Country/Location	Organization	Date
Hypertension	CN	Guangxi Nanning Baihui Pharmaceutical Group Co., Ltd	01 Jan 1982

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