Source: Pharmaceutical Technology
The companies will develop gene therapies for ocular diseases under the new deal. Credit: elenavolf / Shutterstock.com. Source: Pharmaceutical Technology
The parties will focus on developing intravitreally delivered AAVs.
Source: Pharmaceutical Technology
Source: Pharmaceutical Technology
ReportsLOA and PTSR Model - Gene Therapy To Target Cd33 And Cll1 For Oncology in Myeloproliferative Diso... GlobalData The AAVid capsid discovery platform and transgene engineering technology of ShapeTX will be combined with the capabilities of Otsuka in genetic payload design and ophthalmology. ShapeTX is entitled to receive an initial undisclosed payment from Otsuka. Otsuka will also make developmental, regulatory and sales-based milestone payments totalling more than $1.5bn. Based on potential sales of products developed by the partnership, ShapeTX will also receive tiered royalty payments. ShapeTX’s artificial intelligence (AI)-powered AAVid platform merges throughput screening of numerous AAV variants and machine learning to detect new AAV capsids for direct-to-NHP in vivo selection to enhance clinical translation. ShapeTX will also use its transgene engineering technology to optimise payloads of Otsuka for therapeutic gene expression levels in directed cell types. The collaboration offers options to include other targets and tissue types in the future.
“Our collaboration with ShapeTX aims to enable the delivery of vectorised antibody drugs in combination with AAV, in order to target specific disease cell types in the eye and provide a once-in-a-lifetime and curative administration with stable lifetime expression. “This holds the potential to become dramatically beneficial to patients who have suffered from specific chronic ocular diseases.” Cell & Gene Therapy coverage on Pharmaceutical Technology is supported by Cytiva.
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Free WhitepaperCell and gene therapies: Pipe dream to pipeline The cell and gene industry is gaining momentum, with a new wave of therapies promising to transform the way doctors treat, and even cure, disease. In this report, Cytiva and GlobalData have collaborated to explore the rise of the cell and gene therapy industries, the current state of the market, present and future opportunities for advancement, and the challenges that lie ahead.By Cytiva Thematic Source: Pharmaceutical Technology
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