Creative Bioarray Developed Comprehensive Immortalized Cell Lines to Speed Biomedical Research
23 Mar 2023
New York, Mar 22th, 2023 - Creative Bioarray, one of the top leading biotechnology products and services providers, is dedicated to providing products and technologies for multiplexing cell-based assays in drug discovery and development, including primary cells, immortalized cell lines, and recombinant cell lines. With a proprietary technology for GPCR screening, Creative Bioarray is able to identify the compounds with the highest effectiveness but avoid the undesired side effects. Recently, Creative Bioarray announced the launch of its comprehensive immortalized cell lines to speed biomedical research.
Immortalized cells are derived from primary cells: introduce exogenous immortalized genes (recombinant lentivirus, retrovirus & adenovirus EBV, HPV E6/7 and SV40 T antigens, hTERT, p53) into target cells by gene transfection technology, to establish immortalized cell lines, to achieve in vitro cell culture, so that the cells cultured in vitro have the ability to proliferate, and there is no difference between cells. Through immortalization, cells that are difficult to pass on, slow to proliferate, and prone to aging can be immortalized, thereby providing researchers with more cell resources and providing well in vitro cell model for scientific research. Creative Bioarray has a comprehensive line of immortalized cells, including human-immortalized cells, mouse-immortalized cells, and rat-immortalized cells, and also provides customized cell immortalization services for customers' unique solutions.
Generate immortality by isolating from naturally occurring cancers or introducing viral genes that partially deregulate the cell cycle (eg, adenovirus type 5 E1 gene used to immortalize HEK 293 cell lines; Epstein-Barr virus immortalizes cells) Infected cell line B lymphocytes. ) Creative Bioarray can provide human and animal primary cells immortalized with SV40 antigen T and other immortalization techniques. All immortalized cell lines have been characterized for specific markers and others for functional assays.
Independent studies of spontaneously immortalized clones from different mouse strains have shown that the majority of these clones have one or two mutant p53 alleles compared to their wild-type p53-expressing parental cells. Immortal clones expressing wild-type p53 were found to be defective in one or other elements of the pRb pathway. Creative Bioarray can provide you with immortalized mouse cell lines and an integrated platform to meet the needs of almost any relevant research project.
“In addition, Creative Bioarray offers derivatives of immortalized cells including cell pellets, cDNA, RNA, and extracellular vesicles.” said Hannah Cole, the marketing director of Creative Bioarray, she also added, “Creative Bioarray serves the needs of biomedical scientists in academic research, and R&D of pharmaceutical and diagnostic products in their pursuit of discoveries and innovations.”
About Creative Bioarray
Creative Bioarray is dedicated to offering customers innovative biotechnology products and services for research use to greatly enhance and drive innovation and standards in science. As a well-recognized industry leader with more than 10 years of experience and in-house expert support, Creative Bioarray has already countenanced research all around the world.
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