CFT8634 Phase 1 Dose Escalation Data to be Presented at the Connective Tissue Oncology Society Annual Meeting on November 2, 2023 WATERTOWN, MA, USA I October 11, 2023 I C4 Therapeutics, Inc. (C4T) (Nasdaq: CCCC), a clinical-stage biopharmaceutical company dedicated to advancing targeted protein degradation science to develop a new generation of small-molecule medicines and transform how disease is treated, today announced plans to share data from the Phase 1 dose escalation portions of the ongoing Phase 1/2 trials of CFT7455 and CFT8634. The CFT8634 Phase 1 dose escalation data has been accepted as a poster presentation at the Connective Tissue Oncology Society (CTOS) Annual Meeting taking place from November 1 – 4, 2023 in Dublin, Ireland. C4T will host a company-sponsored event on December 12, 2023, to share the CFT7455 dose escalation data in relapsed/refractory multiple myeloma (R/R MM). The Phase 1/2 trial is designed to characterize safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and evidence of anti-tumor activity of CFT8634 based on RECIST 1.1 criteria. As of August 29, 2023, 32 patients were enrolled across six dose escalation cohorts using a daily dosing schedule. CTOS Presentation Details
Format: Poster Presentation
Time: Thursday, November 2, 2023; 5:30 PM – 6:30 PM IST (9:00 AM EST)
Presenter: Mark Agulnik, M.D., sarcoma section chief, department of medical oncology and therapeutics research, City of Hope Data included in the poster presentation will be PK, PD, safety and RECIST criteria efficacy measures.
The Phase 1/2 trial is designed to characterize the safety, tolerability, PK, PD and anti-tumor activity of CFT7455 in patients with R/R MM or relapsed/refractory non-Hodgkin’s lymphoma (R/R NHL). The Phase 1 dose escalation portion of the ongoing Phase 1/2 trial has utilized a 14 days on/14 days off dosing schedule within which both daily dosing and Monday/Wednesday/Friday dosing were explored. C4T has completed the Phase 1 dose escalation for CFT7455 as a monotherapy in R/R MM using a 14 days on/14 days off dosing schedule; 22 patients were enrolled across five dose escalation cohorts for this portion of the study. Enrollment continues for the Phase 1 dose escalation evaluating CFT7455 with dexamethasone in R/R MM and as a monotherapy in R/R NHL. At a company-sponsored event on December 12, 2023, C4T plans to present Phase 1 dose escalation data that focuses on the CFT7455 monotherapy regimen in R/R MM. Upcoming Investor Conferences
The company is planning to participate in the following upcoming investor conferences:
C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transforms patients’ lives. C4T is leveraging its TORPEDO® platform to efficiently design and optimize small-molecule medicines that harness the body’s natural protein recycling system to rapidly degrade disease-causing proteins, offering the potential to overcome drug resistance, drug undruggable targets and improve patient outcomes. C4T is advancing multiple targeted oncology programs to the clinic and expanding its research platform to deliver the next wave of medicines for difficult-to-treat diseases. For more information, please visit www.c4therapeutics.com.