Source: Pharmaceutical Technology
Source: Pharmaceutical Technology
CAR-T therapies have proven to be successful in the management of select haematologic malignancies. However, many patients relapse due to a lack of long-term T cell effector function. The therapeutic avenues available post-relapse after CAR-T therapy are limited, underscoring the need for new therapies that can augment current survival outcomes.
Verismo’s KIR-CAR platform uses natural killer (NK) cell-derived KIR and DAP12 split signalling to activate and stimulate the immune system, helping CAR-T cells stay active for longer and fight against both solid tumours and blood cancers. SynKIR-19 targets and destroys cells with CD19, a protein found in B lymphocytes. It binds to overexpressed tumour antigens, activating T cells and triggering targeted killing of tumour cells. See Also:Circular RNA: Vaccines, therapeutics and biomarkers could be revolutionised
Source: Pharmaceutical Technology
The cell therapy startup spun out of the University of Pennsylvania in 2020. It has since raised $50m, generating $17m in a second pre-Series A round co-led by DongKoo Bio, HLB Innovation and HLB in July 2023. Verismo established a research and development centre at CIC Philadelphia in 2022 to advance its KIR-CAR platform. According to a report on GlobalData’s Pharma Intelligence Center, the number of diagnosed prevalent cases of B-cell NHL will exceed 1.8 billion in 2027 globally. In the announcement accompanying the IND, Verismo’s chief scientific officer Laura Johnson said: “The SynKIR-310 technology is designed to enhance the anti-tumour activity and extend the efficacy of T cells. This could potentially improve persistence and prevent early disease relapse in patients with aggressive lymphomas. SynKIR-310 could be especially beneficial for patients that relapsed after previous infusions of CAR T cell therapies.” Cell & Gene Therapy coverage on Pharmaceutical Technology is supported by Cytiva. Editorial content is independently produced and follows the highest standards of journalistic integrity. Topic sponsors are not involved in the creation of editorial content.
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Source: Pharmaceutical Technology
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