Not Enough Antibiotics in Drug Development Pipeline, WHO Says
30 Mar 2023
Phase 3Qualified Infectious Disease Product
THURSDAY, March 30, 2023 -- Only 12 new antibiotics entered the market between 2017 and 2021, and too few currently are under development against critical pathogens, according to a World Health Organization presentation at the 33rd European Congress of Clinical Microbiology & Infectious Diseases, held from April 15 to 18 in Copenhagen, Denmark.
Valeria Gigante, Ph.D., from the WHO Antimicrobial Resistance Division in Geneva, and colleagues updated the state of the antibiotic landscape. They reported that of the 12 antibiotics approved, only cefiderocol is able to target all the pathogens deemed critical by WHO. Of the 27 antibiotics currently under development, only solithromycin, which is used to treat community-acquired pneumonia and other infections, is awaiting market authorization and seven are in phase 3 trials. Only four of the 27 have new mechanisms of action, and most are not new drug classes. Only six of the 27 are considered innovative enough to overcome antibiotic resistance using WHO criteria, and only two of the six target highly drug-resistant forms of these microbes.
"There is a major gap regarding products addressing multidrug resistant pathogens, such as Acinetobacter baumannii and Pseudomonas aeruginosa," Gigante said in a statement. "Few new innovative antibiotics are expected in the coming years. We have no silver bullets."
More Information
Posted March 2023
For more details,please visit the original website
The content of the article does not represent any opinions of Synapse and its affiliated companies. If there is any copyright infringement or error, please contact us, and we will deal with it within 24 hours.
Organizations
-Targets
-Chat with Hiro
Hot reports
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.