Pliant Therapeutics Presents Data from its Bexotegrast Program at the European Association for the Study of the Liver (EASL) International Liver Congress™
Pliant Therapeutics Presents Data from its Bexotegrast Program at the European Association for the Study of the Liver (EASL) International Liver Congress™
SOUTH SAN FRANCISCO, Calif., June 06, 2024 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (Nasdaq: PLRX), a late-stage biotechnology company and leader in the discovery and development of novel therapeutics for the treatment of fibrotic diseases, today announced two poster presentations, including a late-breaker, were presented at the European Association for the Study of the Liver (EASL) International Liver Congress™ being held June 5-8, 2024.
“We were pleased to share our latest data from our bexotegrast program in PSC including positive topline results from our Phase 2a INTEGRIS-PSC trial. These data represent the progress we continue to make in advancing this novel drug in fighting fibrotic liver disease. We look forward to presenting additional data from INTEGRIS-PSC in the coming weeks,” said Éric Lefebvre, M.D., Chief Medical Officer at Pliant Therapeutics.
In a late breaker oral presentation, Michael Trauner, M.D., Chair of Gastroenterology and Hepatology, Department of Medicine III at the Medical University Clinic in Vienna, Austria presented interim results from the ongoing randomized, placebo-controlled Phase 2a INTEGRIS-PSC trial. Results showed that bexotegrast was well tolerated across all dose cohorts over 12 weeks of treatment. Across all doses tested, bexotegrast attenuated increases in enhanced liver fibrosis (ELF) scores and pro-peptide of type III collagen formation (PRO-C3) when compared to placebo supporting bexotegrast’s antifibrotic mechanism of action.
In a poster presentation, Johanna Schaub, Ph.D., Principal Scientist II, Translational Sciences, at Pliant Therapeutics presented results from differential gene expression analysis of bexotegrast in human precision-cut liver slices with biliary fibrosis performed at the single cell level. Inhibition with bexotegrast showed a differentiated profile from TGF-β receptor (ALK5) inhibition. Bexotegrast targeted reduction of TGF-β signaling, a master regulator in fibrosis, in fibrogenic cells, with attenuated effects on cell types associated with the immunomodulatory functions of TGF-β.
Posters presented at the 2024 (EASL) International Liver Congress™ are available on Pliant’s website under the Publications section at https://pliantrx.com/publications.
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