AUSTIN, Texas, HAMILTON, ON and SAN DIEGO, Dec. 19, 2023 /PRNewswire/ -- Triumvira Immunologics, a clinical-stage company developing novel, targeted autologous and allogeneic T cell therapeutics that co-opt the natural biology of T cells to treat patients with solid tumors, today announced that it will present two abstracts at the 2024 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium in San Francisco, California, from January 18-20, 2024. The company will showcase clinical data from its ongoing Phase I/II studies investigating the safety and efficacy of autologous TAC-T cells targeting human epidermal growth factor receptor 2 (HER2) and Claudin 18.2 (CLDN 18.2), respectively, in relapsed or refractory solid tumors (TACTIC-2 /NCT04727151, TACTIC-3 /NCT05862324). The technology behind TAC01-HER2 and TAC01-CLDN18.2 stands as an innovative cell-based therapeutic modality, harnessing genetically engineered T cells derived autologously. These T cells are equipped with a T-cell Antigen Coupler (TAC) rationally designed to specifically recognize HER2 or CLDN18.2 within tumor cells. Details of the abstracts for each poster presentation are as follows:
Authors: Benjamin L. Schlechter, Ecaterina Dumbrava, Mridula George, Samuel Saibil, Marcus Butler, Antonio Giordano, Rishi Surana, Chih-Yi Liao, Jordan Weiss, Brooke Pieke, Miriam Gavriliuc, Emily Lichtenstein, Maria Apostolopoulou, Courtney Burke, Bushra Qureshi, Deyaa Adib, & Daniel Olson.
Date: Thursday, January 18 at 11:45 a.m. - 1:15 p.m. Pacific Time
Location: Level 1, West Hall, Poster Board M2
Authors: Ecaterina Dumbrava, Davendra Sohal, Daniel Olson, Samuel Saibil, Alejandro Urgelles, Maria Apostolopoulou, Amy Mueller, Kara Moss, Deyaa Adib, Benjamin Schlechter, & Syma Iqbal.
Date: Thursday, January 18 at 11:45 a.m. - 1:15 p.m. Pacific Time
Location: Level 1, West Hall, Poster Board N4
Triumvira Immunologics, Inc. ("Triumvira") is a leading clinical-stage solid tumor cell therapy company developing unique, non-gene edited, first-in-class targeted autologous and allogeneic T cell therapeutics that co-opt the natural biology of T cells to treat patients with solid tumors. The company's proprietary T cell Antigen Coupler (TAC) technology platform activates natural T cell functions differently from other cell therapies such as CAR-T and engineered T cell receptor (TCR) therapies, resulting in clinically safe, effective and redosable cell therapies. Triumvira is developing a broad pipeline targeting promising tumor-associated antigens such as HER2, Claudin 18.2, GUCY2C and GPC3. Triumvira is headquartered in Austin, Texas, with research facilities in Hamilton, Ontario and additional operations in San Diego, California. David Schull or Ignacio Guerrero-Ros, Ph.D.