Solid Biosciences to Present at the American Society of Gene and Cell Therapy Annual Meeting

07 May 2024
www.globenewswire.com
Gene TherapyClinical StudyCell TherapyASH
Solid Biosciences to Present at the American Society of Gene and Cell Therapy Annual Meeting
— Presentations to highlight AAV manufacturing and purification improvements, vector biology updates,
and a comprehensive non-clinical data overview of the company’s lead SGT-003 program —
CHARLESTOWN, Mass., May 07, 2024 (GLOBE NEWSWIRE) -- Solid Biosciences Inc. (Nasdaq: SLDB), a life sciences company developing precision genetic medicines for neuromuscular and cardiac diseases, will present an oral presentation and six posters and at the American Society of Gene and Cell Therapy (ASGCT) 2024 Annual Meeting, Baltimore, May 7-11.
The data presentations will focus on Solid Biosciences’ research and manufacturing capabilities aimed at advancing the field of gene therapy. They will cover various aspects of adeno-associated vector (AAV) manufacturing, novel capsid development, and non-clinical studies with a particular emphasis on the company's lead SGT-003 program.
"We are excited to share our latest scientific findings and advancements at the ASGCT Annual Meeting," said Bo Cumbo, President and Chief Executive Officer at Solid Biosciences. "Our presentations underscore our commitment to developing innovative therapies that address unmet medical needs in neuromuscular and cardiac diseases. We look forward to engaging with the gene therapy community and advancing the field together."
The presentations will feature advancements in gene therapy manufacturing, featuring novel mechanisms to enhance AAV production and refine purification methods. Additionally, innovative approaches in vector biology will be presented, leveraging in silico modeling for AAV vector design and showcasing capsid modifications for improved cardiac tissue targeting. Highlights from non-clinical studies of SGT-003 also will be shared, including findings on microdystrophin expression and functional efficacy in mouse models.
The presentations will cover key areas of Solid Biosciences' research and development initiatives, including:
Oral Presentation
A6 - AAV Vectors - Product Development Manufacturing and Approval Considerations
Novel Mechanism to Increase AAV Yield through Blocking AAV Transduction of Manufacturing HEK293 Cells During AAV Production
Lead Author: Xiaofei E
Abstract #28
May 7, 2:15-2:30pm ET
Poster Presentations
Process Development & Manufacturing
High-Throughput Workflows to Accelerate Development of Chromatographic Purification of rAAV Viral Vectors
Lead Author: Ryan DeGroot
Abstract 1543
May 10, 12:00-1:30pm ET
Identification of an AAV Affinity Chromatography Elution Buffer that Maximizes Product Recovery and Minimizes Product Degradation
Lead Author: Sierra VanSuch
Abstract 1517
May 10, 12:00-1:30pm ET
Increasing Quality and Productivity with Dual Transfection (DT) for AAV Production
Lead Author: Sarath Mandava
Abstract 1541
May 10, 12:00-1:30pm ET
Engineered Cardioskeletal-Directed AAV Capsids That Detarget the Liver
Lead Author: Widler Casy
Abstract 480
May 8, 12:00-1:30pm ET
Designing Therapeutic Recombinant AAV Vectors Using In Silico Vector Modeling
Lead Author: Ethan Waple
Abstract 466
May 8, 12:00-1:30pm ET
Non-Clinical Studies
Systemic Delivery of SGT-003 Microdystrophin Gene Therapy Using the Novel Capsid AAV-SLB101 Ameliorates Muscle Pathology and Rescues Muscle Function in the mdx Mouse Model of Duchenne Muscular Dystrophy
Lead Author: Jamie Marshall
Abstract 1391
May 9, 5:30-7pm ET
Solid Biosciences is a life sciences company focused on advancing a portfolio of gene therapy candidates including SGT-003 for the treatment of Duchenne muscular dystrophy (Duchenne), SGT-501 for the treatment of catecholaminergic polymorphic ventricular tachycardia (CPVT), AVB-401 for the treatment of BAG3-mediated dilated cardiomyopathyBAG3-mediated dilated cardiomyopathy, and additional assets for the treatment of fatal cardiac diseases. Solid is advancing its diverse pipeline across rare neuromuscular and cardiac diseases, bringing together experts in science, technology, disease management, and care. Patient-focused and founded by those directly impacted, Solid’s mandate is to improve the daily lives of patients living with these devastating diseases. For more information, please visit www.solidbio.com.
Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including statements regarding future expectations, plans and prospects for the company; the company’s planned oral and poster presentations; and other statements containing the words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “would,” “working” and similar expressions. Any forward-looking statements are based on management’s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in, or implied by, such forward-looking statements. These risks and uncertainties include, but are not limited to, risks associated with the ability to recognize the anticipated benefits of Solid’s acquisition of AavantiBio; the company’s ability to advance SGT-003, SGT-501, AVB-401 and other preclinical programs and capsid libraries on the timelines expected or at all; obtain and maintain necessary approvals from the FDA and other regulatory authorities; replicate in clinical trials positive results found in preclinical studies of the company’s product candidates; obtain, maintain or protect intellectual property rights related to its product candidates; compete successfully with other companies that are seeking to develop Duchenne and other neuromuscular and cardiac treatments and gene therapies; manage expenses; and raise the substantial additional capital needed, on the timeline necessary, to continue development of SGT-003, SGT-501, AVB-401 and other candidates, achieve its other business objectives and continue as a going concern. For a discussion of other risks and uncertainties, and other important factors, any of which could cause the company’s actual results to differ from those contained in the forward-looking statements, see the “Risk Factors” section, as well as discussions of potential risks, uncertainties and other important factors, in the company’s most recent filings with the Securities and Exchange Commission. In addition, the forward-looking statements included in this press release represent the company’s views as of the date hereof and should not be relied upon as representing the company’s views as of any date subsequent to the date hereof. The company anticipates that subsequent events and developments will cause the company's views to change. However, while the company may elect to update these forward-looking statements at some point in the future, the company specifically disclaims any obligation to do so.
Media Contact:
Glenn Silver
FINN Partners
glenn.silver@finnpartners.com


For more details,please visit the original website
The content of the article does not represent any opinions of Synapse and its affiliated companies. If there is any copyright infringement or error, please contact us, and we will deal with it within 24 hours.
Organizations
Indications
Targets
Drugs
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Leverages most recent intelligence information, enabling fullest potential.