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MechanismFGFR4 antagonists |
Active Org.- |
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Active Indication- |
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Drug Highest PhaseSuspended |
First Approval Ctry. / Loc.- |
First Approval Date- |
EVER4010001联合帕博利珠单抗用于晚期实体瘤患者中剂量递增和选定适应症的I/II期研究
[Translation] A Phase I/II Study of EVER4010001 in Combination with Pembrolizumab for Dose Escalation and Select Indications in Patients with Advanced Solid Tumors
主要目的:确定EVER4010001与Pembrolizumab联合给药的最大耐受剂量(MTD)以及推荐II期剂量(RP2D)。次要目的:表征该联合治疗时的药代动力学(PK)和个体药物暴露;获得该联合治疗时抗肿瘤活性的初步评估结果;评估该联合治疗时的安全性和耐受性;探讨预测性生物标记物。
[Translation] Primary objective: To determine the maximum tolerated dose (MTD) and recommended phase II dose (RP2D) of EVER4010001 combined with pembrolizumab. Secondary objectives: To characterize the pharmacokinetics (PK) and individual drug exposure of the combination therapy; To obtain preliminary evaluation results of the anti-tumor activity of the combination therapy; To evaluate the safety and tolerability of the combination therapy; To explore predictive biomarkers.
100 Clinical Results associated with EverNov Medicines (Zhuhai Hengqin) Limited
0 Patents (Medical) associated with EverNov Medicines (Zhuhai Hengqin) Limited
100 Deals associated with EverNov Medicines (Zhuhai Hengqin) Limited
100 Translational Medicine associated with EverNov Medicines (Zhuhai Hengqin) Limited