Aidan McNamee
Close Up Of Senior Man Suffering With Parkinson’s disease. Selvita believes its collaboration with the University of Oxford could produce novel new treatments for Parkinson’s Disease. Source: Getty Images / Highwaystarz-Photography
The Polish drug discovery and service provider Selvita has announced a new collaboration with the University of Oxford to advance the development of Parkinson’s disease therapies.
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Parkinson’s is caused by a build-up of alpha-synuclein, a small protein, forming aggregates inside vulnerable neurons. Cells are then unable to efficiently clear these aggregates, potentially killing neurons and allowing the disease to progress.
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The team at Oxford, led by George Tofaris, PhD, Professor of Neurology and Translational Neuroscience at the university, has identified key protein disposal factors that affect alpha-synuclein aggregation. Selvita believes these could be important drug targets for disease modification, preventing its progression further,
as per a 5 June press release.
In an email to
Pharmaceutical Technology
, a Selvita spokesperson stated the company’s plans to build from the team’s research to develop protein degraders. By combining academic knowledge of the disease’s biology from Oxford, and Selvita’s own technical drug discovery capabilities, the company believes the collaboration best positioned them to develop protein degraders.
Parkinson’s disease is the second most common neurodegenerative disease, with roughly seven million people affected worldwide. Despite this, existing treatments are only symptomatic, unable to slow or stop the disease’s progression.
A GlobalData analysis found a lack of disease-modifying therapies (DMTs) for Parkinson’s was
one of the highest unmet needs
. Any company that could provide DMTs would have ample opportunities for market entry, as they could bring about a major shift in patient treatment.
GlobalData is the parent company of
Pharmaceutical Technology
.
Across the seven major markets (US, UK, Japan, Germany, France, Spain and Italy) the market for Parkinson’s disease treatment is set to grow significantly over the next few years, from $4.6bn in 2023 to $11.5bn. The US market is driving this growth, forecasted to nearly triple from $2.4bn in 2023 to $7.4bn by 2029, as per GlobalData.
At this stage, the Selvita spokesperson said it would be premature to commit to any development timeline, but added that they were hopeful to see applications go to trial in the future.
Early R&D projects coverage on Pharmaceutical Technology is supported by Mimotopes
.
Editorial content is independently produced and follows the
highest standards
of journalistic integrity. Topic sponsors are not involved in the creation of editorial content.
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Peptide libraries are a powerful tool in biological research for screening large numbers of peptides in the search for the few, critical bioactive peptides.
Mimotopes PepSets are custom-synthesized peptide libraries supplied unpuried for fast, efcient screening work. These sets of chemically synthesized individual peptides are made
on a small scale using Mimotopes’ unique proprietary parallel array synthesis platform. PepSets comprising hundreds, or even thousands of peptides, are rapidly synthesized and shipped within a few weeks of ordering.
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USA (+1)
Algeria (+213)
Andorra (+376)
Angola (+244)
Anguilla (+1264)
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Armenia (+374)
Aruba (+297)
Australia (+61)
Austria (+43)
Azerbaijan (+994)
Bahamas (+1242)
Bahrain (+973)
Bangladesh (+880)
Barbados (+1246)
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Laos (+856)
Latvia (+371)
Lebanon (+961)
Lesotho (+266)
Liberia (+231)
Libya (+218)
Liechtenstein (+417)
Lithuania (+370)
Luxembourg (+352)
Macao (+853)
Macedonia (+389)
Madagascar (+261)
Malawi (+265)
Malaysia (+60)
Maldives (+960)
Mali (+223)
Malta (+356)
Marshall Islands (+692)
Martinique (+596)
Mauritania (+222)
Mayotte (+269)
Mexico (+52)
Micronesia (+691)
Moldova (+373)
Monaco (+377)
Mongolia (+976)
Montserrat (+1664)
Morocco (+212)
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Myanmar (+95)
Namibia (+264)
Nauru (+674)
Nepal (+977)
Netherlands (+31)
New Caledonia (+687)
New Zealand (+64)
Nicaragua (+505)
Niger (+227)
Nigeria (+234)
Niue (+683)
Norfolk Islands (+672)
Northern Marianas (+670)
Norway (+47)
Oman (+968)
Palau (+680)
Panama (+507)
Papua New Guinea (+675)
Paraguay (+595)
Peru (+51)
Philippines (+63)
Poland (+48)
Portugal (+351)
Puerto Rico (+1787)
Qatar (+974)
Reunion (+262)
Romania (+40)
Russia (+7)
Rwanda (+250)
San Marino (+378)
Sao Tome & Principe (+239)
Saudi Arabia (+966)
Senegal (+221)
Serbia (+381)
Seychelles (+248)
Sierra Leone (+232)
Singapore (+65)
Slovak Republic (+421)
Slovenia (+386)
Solomon Islands (+677)
Somalia (+252)
South Africa (+27)
Spain (+34)
Sri Lanka (+94)
St. Helena (+290)
St. Kitts (+1869)
St. Lucia (+1758)
Sudan (+249)
Suriname (+597)
Swaziland (+268)
Sweden (+46)
Switzerland (+41)
Syria (+963)
Taiwan (+886)
Tajikstan (+7)
Thailand (+66)
Togo (+228)
Tonga (+676)
Trinidad & Tobago (+1868)
Tunisia (+216)
Turkey (+90)
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Turkmenistan (+993)
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Year France Germany Italy Japan Spain United Kingdom United States
2019 121.03 578.55 134.29 644.01 105.83 121.46 1809.79
2020 121.31 573.68 134.18 667.06 105.74 121.97 2047.18
2021 121.65 582.45 135.06 694.66 108.52 121.88 2201.58
2022 123.88 592.76 136.43 727.51 113.65 121.06 2454.66
2023 127.93 603.83 139.29 756.99 119.56 123.35 2695.67
2024 135.23 621.67 144.23 778.77 124.95 130.11 3025.33
2025 154.41 653 152.57 793.72 132.98 138.15 3537.76
2026 184.52 706.16 164.95 846.33 144.8 148.97 4833.98
2027 256.18 947.17 215 885.81 199.27 179.63 5657.51
2028 360.63 1257.17 329.89 935.27 308.88 219.35 6376.5
2029 471.86 1556.14 426.22 1007.13 385.65 257.36 7390.18