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Otorhinolaryngologic Diseases

Nervous System Diseases

Respiratory Diseases

Conjugated vaccine

Prophylactic vaccine

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Disease Domain	Count

Infectious Diseases	1
Nervous System Diseases	1

Top 5 Drug Type	Count

Conjugated vaccine	1
Prophylactic vaccine	1

AbstractA polarographic method has been developed for the determination of an antidepressant, 10-(m-chlorophenyl)-2,3,4,10-tetrahydropyrimido [1, 2a] indol-10-ol hydrochloride. The method is not subject to interference from the immediate precursor in the synthetic route of drug preparation or the products of thermal degradation of the active drug substance. The method may be used to monitor storage stability studies.

12 Apr 2011·Journal of Pharmacy and PharmacologyQ3 · MEDICINE

Central nervous system stimulant action of fenfluramine in rabbits

Q3 · MEDICINE

Article

Author: Mayer, Susan R ; Wilson, A B ; Southgate, P J

Fenfluramine-HCl, an anorectic drug structurally similar to amphetamines, had central nervous system stimulant effects in conscious and pentobarbitone-anesthetized rabbits similar to those of d-amphetamine sulfate when administered in doses greater than those used therapeutically.

12 Apr 2011·Journal of Pharmacy and PharmacologyQ3 · MEDICINE

Amphetamine Toxicity in Aggregated Mice

Q3 · MEDICINE

Article

Author: Askew, Beryl M

From the temperature rise in individual mice it was possible to predict with reasonable accuracy whether or not a particular animal would die following an intraperitoneal injection of amphetamine below 100 mg./kg.All of the mice survived when their rectal temperature remained below 41.8°.In contrast, with one exception, all mice whose temperature rose above 42.4° died.The results indicated that hyperpyrexia was probably an important factor contributing to the increased toxicity of amphetamine to aggregated mice.Although doses of amphetamine approximating the L.D.₅₀ increased the body temperature of the isolated mice, the rectal temperature did not rise above 41.8° in any of the animals.

100 Deals associated with John Wyeth & Brother Ltd.

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100 Translational Medicine associated with John Wyeth & Brother Ltd.

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Pipeline

Pipeline Snapshot as of 27 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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