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Last update 08 May 2025

Northwestern Polytechnical University Shenzhen Research Inst.

Company|2002|Guangdong Sheng, China|

www.dirrs.cn

Company|2002|Guangdong Sheng, China|

www.dirrs.cn

Last update 08 May 2025

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Pipeline

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Translational Medicine

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100 Clinical Results associated with Northwestern Polytechnical University Shenzhen Research Inst.

0 Patents (Medical) associated with Northwestern Polytechnical University Shenzhen Research Inst.

Literatures (Medical) associated with Northwestern Polytechnical University Shenzhen Research Inst.

01 Jul 2025·IEEE Transactions on Power Electronics

Sliding Mode Observer-Based Robust Switch Fault Diagnosis of Bidirectional Interleaved Converters for Energy Storage System

Author: Zhang, Ruixin ; Huangfu, Yigeng ; Ma, Yuqi ; Zhuo, Shengrong ; Gao, Fei

01 May 2025·Biochemical and Biophysical Research Communications

RPS15a knockdown impedes the progression of B-ALL by inducing p53-mediated nucleolar stress

Article

Author: Meng, Wenting ; Huang, Siyong ; Nie, Fengze ; Li, Xinxin ; Di, Sijia

Ribosome biogenesis is intricately linked to the pathogenesis of B-cell acute lymphoblastic leukemia (B-ALL), but the precise regulatory mechanisms remain to be elucidated. First of all, our study identify that RPS15a, the ribosomal small subunit structural protein, is significantly higher expressed in B-ALL patients, indicating a potential crucial role of RPS15a in modulating B-ALL progression. Next in importance, our findings found that RPS15a knockdown (KD) results in the impede of cell proliferation and cell cycle progression, while concurrently inducing apoptosis of B-ALL cells. Next, we used immunofluorescence staining of nucleolar proteins NPM1 and FBL to evaluate whether RPS15a KD-mediated abnormal nucleolar ribosome assembly triggers nucleolar stress. Our findings revealed that, in comparison to control B-ALL cells, RPS15a KD disrupted the localization of NPM1 and FBL within the nucleus, altered the normal architecture of the nucleolus, and induced nucleolar stress. Mechanistically, our study found that RPS15a KD impairs the ribosomal biogenesis by suppressing the synthesis and processing of ribosomal RNAs (rRNAs), including pre-rRNA, 18S rRNA, 28S rRNA, and 5.8S rRNA. Then, we observed that the depletion of RPS15a leads to the activation of p53 signaling, accompanied by an increase in the protein expression of p53 and p21, which are critical signals that induce nucleolar stress. Furthermore, our rescue experiment involving p53 KD found that the suppression of p53, following RPS15a KD, can alleviate ribosomal biogenesis, facilitate cell cycle progression and inhibit apoptosis. In conclusion, these findings suggest that RPS15a primarily regulates the progression of B-ALL by modulating p53 signaling-mediated nucleolar stress, thereby identifying RPS15a as a critical target for B-ALL treatment.

16 Apr 2025·ACS Applied Materials & Interfaces

Constructing Type-II Band Alignment of 3D/2D Heterojunction for Improved Carrier Transport in Carbon-Based Perovskite Solar Cells

Article

Author: Mao, Jianming ; Geng, Mengqi ; Xu, Tingting ; Shi, Chenyu ; Li, Jialiang ; Lu, Dan ; Jiang, Le

High defect density and low stability remain significant obstacles in the development of efficient and stable 3D perovskite solar cells (PSCs), while 3D/2D hybrid PSCs have emerged as promising candidates due to their excellent environmental tolerance. However, the performance of 3D/2D PSCs might be further limited by carrier transport within the films caused by quasi-2D phases with multiple n-values. Herein, precrystallized 2D phenylethylamine lead iodide (PEA₂PbI₄) crystals and methylammonium chloride (MACl) were introduced into the bulk phase of methylammonium lead iodide (MAPbI₃) to improve crystal quality and growth orientation. During the film formation process, 2D PEA₂PbI₄ delayed crystal nucleation and formed a 3D/2D mixed film. The as-formed type-II band alignment in the 2D/3D heterojunction film restricts the movement of charge carriers within the 3D phase lattice, avoiding the risk of being trapped by defects at the grain boundaries. Additionally, MACl facilitates vertical crystal growth, enlarging grain size and the thickness of perovskite films. Under the combined effect of 2D PEA₂PbI₄ and MACl, the power conversion efficiency (PCE) of the carbon-based PSCs increased from 10.53% to 16.07%. The unpackaged devices retained 90% of their initial PCE after storage for 30 days at room temperature and 40% relative humidity. These findings not only provide a facile way for the crystal tuning and defect passivation by low dimensional perovskites, but also give new insights into constructing efficient 3D/2D types of carbon-based PSCs.

100 Deals associated with Northwestern Polytechnical University Shenzhen Research Inst.

100 Translational Medicine associated with Northwestern Polytechnical University Shenzhen Research Inst.

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Northwestern Polytechnical University Shenzhen Research Inst.

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