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Overview

Iron (II) determination and electrochem. behavior of iron-sucrose complex by pulse polarog. are theor. analyzed.The influence of pulse amplitude of voltage pulse ΔE, pulse time δ and temperature T on height and potential of the first and second polarog. peak is studied with the single factor method.It was found that these three factors had significant influence on the electrochem. behavior of iron-sucrose in pulse polarog.And the USP method for the determination of iron (II) content in iron sucrose injection is discussed in details.Based on the research results in this paper, some advices for improving the analyzing method given by USP are suggested.

Yaowu Shengwu Jishu

Determination of emodin in Gongliuqing tablets by HPLC

Author: Liu, Sai ; Zha, Jing ; Xiong, Shoujun

To establish a HPLC method for determination of emodin in Gongliuqing tablets, the chromatog. column of Merck C₁₈ (150 mm*4.6 mm) was used.The mobile phase consisted of methanol-0.1% phosphoric acid (75:25) and the flow rate was 1.0 mL/min.The detection wavelength was set at 286 nm.The linear response range was 4.09-14.31μg/mL (r = 0.9999).The mean recovery was 100.5% (RSD=1.36%).This method was simple, rapid and accurate.So it was suitable for determination of emodin in Gongliuqing tablets.

Zhongnan Yaoxue

Pharmacokinetics of ursodeoxycholic acid and chenodeoxycholic acid in bear gall powder extract by LC-MS in rats

Author: Guan, Lan ; Miao, Ming-xing ; Wu, Chang-xuan ; Wang, Yi-bing

Objective To establish an LC-MS method to determine ursodeoxycholic acid and chenodeoxycholic acid in rat plasma and to investigate pharmacokinetic properties of ursodeoxycholic acid and chenodeoxycholic acid after an oral administration of bear gall powder extract to rats.Methods Ursodeoxycholic acid and chenodeoxycholic acid and diclofenac (the internal standard, IS) were extracted by liquid-liquid extraction and separated on a Waters Atlantis T3 C₁₈ column, with methanol and water containing 1 mmol·L^-1 ammonium acetate and 0.01% formic acid (24:76) as the mobile phase.Quantitation was carried out by single reaction monitoring in neg. mode on a Shimadzu LC-MS2020 system.After the validation, the developed method was used to evaluate the pharmacokinetics of ursodeoxycholic acid and chenodeoxycholic acid in rats after an oral administration of 100 mg·kg^-1 of bear gall powder extractResults The study showed a good linearity at 0.078-10.0 μg·mL^-1 with a sensitivity of 0.078 μg·mL^-1 as the limit of quantification.The precision, accuracy, stability and mean recoveries were satisfied and met the requirement of biol. sample measurement.The method was successfully applied in the pharmacokinetic study of ursodeoxycholic acid and chenodeoxycholic acid in rat plasma samples.Conclusion This LC-MS method was selective, sensitive and reproducible, and was successfully applied in the pharmacokinetic study of ursodeoxycholic acid and chenodeoxycholic acid in rats.

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Pipeline

Pipeline Snapshot as of 26 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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