The Harbor Branch Oceanographic Institution Foundation, Inc. is dedicated to promoting marine science and engineering research and education. The organization strives to enhance our understanding of oceans and coastal regions by supporting exploration and scientific investigation. Established in 1971 by J. Seward Johnson, Sr., the company is based in Fort Pierce, FL.

100 Clinical Results associated with Harbor Branch Oceanographic Institute Foundation, Inc. (FL)

0 Patents (Medical) associated with Harbor Branch Oceanographic Institute Foundation, Inc. (FL)

Literatures (Medical) associated with Harbor Branch Oceanographic Institute Foundation, Inc. (FL)

01 Mar 2007·Journal of Natural ProductsQ2 · BIOLOGY

Neopeltolide, a Macrolide from a Lithistid Sponge of the Family Neopeltidae

Q2 · BIOLOGY

Article

Author: Reed, John K. ; Linley, Patricia ; Wright, Amy E. ; Harmody, Dedra ; Botelho, Julianne Cook ; Pitts, Tara P. ; Guzmán, Esther ; McCarthy, Peter J. ; Pomponi, Shirley A.

A new marine-derived macrolide designated as neopeltolide (1) has been isolated from a deep-water sponge of the family Neopeltidae. Its structure was elucidated on the basis of spectroscopic data interpretation. Neopeltolide (1) is a potent inhibitor of the in vitro proliferation of the A-549 human lung adenocarcinoma, the NCI-ADR-RES human ovarian sarcoma, and the P388 murine leukemia cell lines, with IC50's of 1.2, 5.1, and 0.56 nM, respectively. Neopeltolide (1) also inhibited the growth of the fungal pathogen Candida albicans with a minimum inhibitory concentration of 0.62 microg/mL.

01 Apr 2001·Journal of Natural ProductsQ2 · BIOLOGY

Microxine, a New cdc2 Kinase Inhibitor from the Australian Marine Sponge Microxina Species

Q2 · BIOLOGY

Article

Author: Killday, K. Brian ; Wright, Amy E. ; Hooper, J. N. A. ; Sills, Matthew A. ; Murphy, Peter T. ; Yarwood, Donna

A new purine derivative microxine (1) was isolated from the Australian marine sponge Microxina sp. The compound was isolated via reversed-phase chromatography and its structure determined spectroscopically. Microxine was found to weakly inhibit cdc2 kinase activity with an IC(50) of 13 microM.

01 Feb 2001·Journal of Natural ProductsQ2 · BIOLOGY

Three New Peroxides from the Sponge Plakinastrella Species

Q2 · BIOLOGY

Article

Author: Killday, K. Brian ; Schimoler, Rebecca ; Chen, Ying ; McCarthy, Peter J. ; Selitrennikoff, Claude ; Wright, Amy E. ; Pomponi, Shirley A. ; Chilson, Katherine

Two new five-membered-ring peroxide acids, plakinic acid F (3) and epiplakinic acid F (4), and a new peroxide-lactone, plakortolide F (5), were isolated from a sponge of the genus Plakinastrella collected from Felicite Island, Seychelles. The structures were elucidated through spectral analysis. The free acids 3 and 4 exhibit moderate antifungal activity against Candida albicans with minimum inhibitory concentrations of 25 micrograms/mL (SDB) and 3.1 micrograms/mL (RPMI) for 3, and 25 micrograms/mL (SDB) and 6.25 micrograms/mL (RPMI) for 4, respectively. Both also showed moderate in vitro inhibition of Aspergillus fumigatus with IC90's of 25 micrograms/mL.

100 Deals associated with Harbor Branch Oceanographic Institute Foundation, Inc. (FL)

100 Translational Medicine associated with Harbor Branch Oceanographic Institute Foundation, Inc. (FL)

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