Comparison of analgesic efficacy of thoracic paravertebral block with Rhomboid Intercostal and SubSerratus block in patients undergoing minimally invasive cardiac surgery

Start Date11 Mar 2019

Sponsor / Collaborator

Sri Jayadeva Institute of Cardiovascular Sciences & Research

CTRI/2019/03/017922

/ Not yet recruitingNot ApplicableIIT

Comparison of epidural analgesia with ultrasound guided bilateral erector spinae plane block in aorto-femoral arterial bypass surgery

Start Date11 Mar 2019

Sponsor / Collaborator

Sri Jayadeva Institute of Cardiovascular Sciences & Research

100 Clinical Results associated with Sri Jayadeva Institute of Cardiovascular Sciences & Research

0 Patents (Medical) associated with Sri Jayadeva Institute of Cardiovascular Sciences & Research

948

Literatures (Medical) associated with Sri Jayadeva Institute of Cardiovascular Sciences & Research

01 May 2025·Journal of Neonatology

Preliminary Evaluation of a Mobile Application-based Tool to Aid Early Detection of Critical Congenital Heart Disease

Author: Sasikumar, Navaneetha ; Raghavannair, Sureshkumar ; B, Harapriya ; Alawani, Sujata ; Sastry, Usha Mandikal Kodanda Rama ; Kumar, Raman Krishna ; D’souza, Sylvia ; Parameshwarannair, Priya ; Kattula, Anusha ; Teli, Akkatai

BackgroundThis study reports the preliminary results of a mobile application (APP)-based tool to aid early detection of critical congenital heart disease (CCHD). The tool is formulated to assist neonatologists/paediatricians in bedside diagnosis by asking a series of clinical and echocardiography-based questions, leading to a conclusion. The study was done with paediatric cardiologists themselves to ascertain the validity of the algorithms.MethodsConsecutive patients with CCHD seen by the participating paediatric cardiologists during the period January 2021 to June 2022 formed the subjects for the study. The routine evaluation and management of the patients were carried out as usual. Later, the treating paediatric cardiologists applied the clinical scenario and echo findings to the ‘Echo Integrated Diagnostic Tool’ of the ‘Smiling Heart APP’. The APP tool performance was recorded. Concurrence between diagnoses made by the two approaches was assessed using kappa statistics. Performance of the APP tool across the spectrum of CHDs was assessed using Fisher’s exact test.Results Out of 69 patients, correct diagnosis was reached by the APP tool in 62 (89.86%). In the rest, (7/69; 11.6%), which mostly comprised of rare diseases, an urgent paediatric cardiology opinion was suggested. The APP tool-based diagnosis was highly accurate, with a kappa value of 1, P < .001 in duct-dependent systemic and pulmonary circulations. In non duct dependent lesions requiring urgent surgery as well as non-urgent surgery, there was substantial agreement, kappa value of 0.723 (95% confidence interval [CI]: 0.549-0.897) and 0.740 (95% CI: 0.575-0.905), respectively. Performance of the APP tool did not vary significantly across the four spectrum of CCHDs (Fisher’s exact test, P value .565). ConclusionsThe APP tool is promising as a bedside aid in diagnosis of common CCHDs and has the potential to bridge the gap in early detection.

01 Apr 2025·Indian Heart Journal

A contemporary review of the head-up tilt test: Utility and limitations

Review

Author: Udyavar, Ameya ; Arora, Vanita ; Gupta, Prabha Nini ; Suri, Pawan ; Naik, Ajay Madhukar ; Kathuria, Sanjeev ; Shenthar, Jayaprakash ; Ramalingam, Vadivelu ; Choudhary, Dinesh ; Singhal, Rahul ; Sutton, Richard ; Rao, B Hygriv ; Mehrotra, Saurabh ; Khanra, Dibbendhu ; Benditt, David

The Head-Up Tilt Test (HUTT) has been widely used for the past four decades as part of the overall assessment of the potential causes of collapse in patients with recurring transient loss of consciousness (TLOC) of unknown cause. The ability of a positive HUTT often to reproduce patient symptoms and illustrate to the patient that the physician is confident of the diagnosis have been major advances in clinical TLOC management. Tilt testing has been particularly important in understanding and diagnosing vasovagal syncope (VVS) and orthostatic hypotension. Despite HUTT having great clinical utility, different HUTT protocols and drug provocations result in different test yields. Limited HUTT reproducibility has led some researchers to criticize HUTT utility. As in most medical tests, limitations are part of the test. Herein, we provide a contemporary review of HUTT's utility in diagnosing and managing various TLOC disorders with intent to clarify its role in clinical practice.

01 Apr 2025·International Journal of Surgery Case Reports

Complex left main bifurcation PCI in a patient with dual positivity: A unique interventional approach – A case report

Article

Author: Kharge, Jayashree ; Sridhar, L ; Kumar, Chethan ; Patil, Rahul ; Setty, H S Natraj ; Natesh, B H

INTRODUCTIONHuman immunodeficiency virus (HIV) affects over 38 million people worldwide, with 26 million receiving combined antiretroviral therapy (CART). People living with HIV (PLWH) have a 1.5- to 2-fold increased risk of cardiovascular disease, yet data on coronary revascularization remain limited. The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), further complicates the management of acute coronary syndrome (ACS) in PLWH. We present a case of an HIV-positive, COVID-19-positive patient with recurrent ACS, requiring urgent percutaneous coronary intervention (PCI) due to hemodynamic instability (systolic BP < 90 mm Hg) and ongoing chest pain despite optimal medical therapy.CASE PRESENTATIONA 41-year-old male, positive for SARS-CoV-2 on RT-PCR, presented with effort angina for two months and recurrent acute chest pain for one day. The electrocardiogram (ECG) showed ST-segment elevation. Despite initial medical management, persistent chest pain and hemodynamic instability (BP 86/60 mm Hg, heart rate 110 bpm) necessitated urgent coronary angiography (CAG), revealing significant stenosis. The SYNTAX Score I for our patient was 12, which is favorable for PCI over CABG. The SYNTAX Score II predicted a 4-year mortality risk of 15.3 % for PCI vs. 5.8 % for CABG. A multidisciplinary heart team discussion favored PCI over CABG. The patient underwent double kissing crush (DK crush) bifurcation stenting with drug-eluting stents (DES), achieving TIMI III flow and resolution of symptoms.CLINICAL DISCUSSIONCoronary revascularization in PLWH is challenging due to a 2- to 3-fold increased risk of myocardial infarction, chronic inflammation, and drug interactions. Additionally, COVID-19 further elevates thrombotic risk. The SYNTAX Score II favored PCI, and considering the patient's unstable condition, PCI was the preferred strategy over CABG to reduce perioperative risks and hospital stay. The DK crush technique is well-documented for complex bifurcation lesions, with studies showing significantly lower target lesion failure rates (4.8 %) than other techniques (10.5 %).CONCLUSIONManaging ACS in PLWH with concurrent COVID-19 requires a multidisciplinary approach. Given the limited surgical data, PCI remains a feasible and effective strategy, particularly in hemodynamically unstable patients. Until randomized trials provide definitive guidance, PCI remains the preferred approach for urgent coronary revascularization in PLWH.

100 Deals associated with Sri Jayadeva Institute of Cardiovascular Sciences & Research

100 Translational Medicine associated with Sri Jayadeva Institute of Cardiovascular Sciences & Research

Corporation Tree

Boost your research with our corporation tree data.

view full example data

Pipeline

Pipeline Snapshot as of 20 Jul 2025

No data posted

Deal

Boost your decision using our deal data.

view full example data

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Profit

Explore the financial positions of over 360K organizations with Synapse.

view full example data

Grant & Funding(NIH)

Access more than 2 million grant and funding information to elevate your research journey.

view full example data

Investment

Gain insights on the latest company investments from start-ups to established corporations.

view full example data

Financing

Unearth financing trends to validate and advance investment opportunities.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Sri Jayadeva Institute of Cardiovascular Sciences & Research

Overview

Related

Corporation Tree

Pipeline

Pipeline Snapshot as of 20 Jul 2025

Deal

Translational Medicine

Profit

Grant & Funding(NIH)

Investment

Financing