Memorial

SAN FRANCISCO, Dec. 07, 2022 (GLOBE NEWSWIRE) -- Nurix Therapeutics, Inc. (Nasdaq: NRIX), a clinical-stage biopharmaceutical company developing targeted protein modulation drugs designed to treat patients with hematologic malignancies and solid tumors, today announced that it will host a live webcast to review clinical data from the Phase 1 clinical trial of its leading BTK degrader program, NX-2127, at 8:30 pm CT (9:30 p.m. ET) on Monday, December 12, 2022. The webcast will feature a presentation by guest speaker, Anthony Mato, M.D., MSCE, lead author for the NX-2127-001 Phase 1 trial update and former director of the Chronic Lymphocytic Leukemia (CLL) Program at Memorial Sloan Kettering Cancer Center, who will provide a clinical update on CLL patients in the Phase 1 trial. It will also feature research on kinase dead BTK mutations that are resistant to BTK inhibitors but are susceptible to clinical stage BTK degraders that was performed in the laboratories of Nurix and its collaborator, Omar Abdel-Wahab, M.D., Chair of Sloan Kettering Institute (SKI) Molecular Pharmacology Program at Memorial Sloan Kettering Cancer Center. The live webcast, as well as a replay, will be available in the Investors section of the Nurix website under Events and Presentations. About NX-2127 NX-2127 is a novel bifunctional molecule that degrades Bruton’s tyrosine kinase (BTK) and cereblon neosubstrates Ikaros (IKZF1) and Aiolos (IKZF3). NX-2127 is currently being evaluated in a Phase 1 clinical trial in patients with relapsed or refractory B cell malignancies. Additional information on the ongoing clinical trial can be accessed at www.clinicaltrials.gov (NCT04830137). About Nurix Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of small molecule drugs and cell therapies based on the modulation of cellular protein levels as a novel treatment approach for cancer and other challenging diseases. Leveraging extensive expertise in E3 ligases together with proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels. Nurix’s wholly owned pipeline includes targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California. For additional information visit http://www.nurixtx.com.

NEW YORK, Aug. 24, 2022 (GLOBE NEWSWIRE) -- SELLAS Life Sciences Group, Inc. (NASDAQ: SLS) (“SELLAS’’ or the “Company”), a late-stage clinical biopharmaceutical company focused on the development of novel therapies for a broad range of cancer indications, today announced results from a new preclinical in vitro study for its highly selective CDK9 inhibitor, GFH009, in neuroendocrine prostate cancer (NEPC). The data shows that GFH009 demonstrated significant anti-tumor effects in the selected cell line at nanomolar concentrations and, in certain samples, complete growth inhibition with no viable cancer cells. NEPC, an aggressive variant of prostate cancer, is a rapidly growing indication which arises as a result of otherwise successful treatment of advanced prostate cancer. In up to 15 to 20 percent of patients treated with hormonal therapies for prostate adenocarcinoma, small-cell prostate cancer may develop in later stages of prostate cancer progression. This histologic transformation occurs as a mechanism of treatment resistance. Aggressive NEPC represents a lethal endpoint in the progression of prostate cancer from prostate adenocarcinoma to castration-resistant prostate cancer (CRPC) to NEPC. Median survival for NEPC patients whose cancer arose from prior prostate adenocarcinoma is estimated at only 5.4 months. The conversion to NEPC is associated with recurrent genetic lesions including mutation or deletion of RB1 and TP53 as well as the overexpression and genomic amplification of MYCN. SELLAS believes that all forms of MYC may be susceptible to CDK9 inhibition and the data from the in vitro study, conducted at an independent, third-party contract research organization, Translational Drug Development (TD2), supported this supposition, resulting in 38 nM median IC50 value. “We are very excited with this first confirmation of our hypothesis that GFH009 could address NEPC, a rapidly growing indication,” said Dragan Cicic, MD, Senior Vice President, Clinical Development, of SELLAS. “About one in eight men will be diagnosed with prostate cancer during his lifetime and any significant change in the course of treatment for this cancer has potential for outsized consequences.” About Translational Drug Development (TD2) TD2 is an oncology development organization that provides innovative services for oncology-focused companies. Using a dedicated team of professionals with broad experience and understanding in drug development, TD2 is uniquely positioned to support improved and accelerated development of medicines for life-threatening oncology diseases. TD2 applies rigorous and high-throughput translational preclinical development, combined with regulatory affairs expertise, to customize clinical trial design and execution. TD2’s suite of capabilities encourages the timely selection of patient populations who are most likely to benefit from a new agent, and the rapid identification of clinically significant endpoints. TD2 is committed to reducing the risks and uncertainty inherent in the drug development process and to the acceleration of patient access to promising treatments. For more information, visit www.TD2inc.com. About SELLAS Life Sciences Group, Inc. SELLAS Life Sciences Group, Inc. (NASDAQ: SLS) is a late-stage clinical biopharmaceutical company focused on the development of novel therapeutics for a broad range of cancer indications. SELLAS’ lead product candidate, galinpepimut-S (GPS), is licensed from Memorial Sloan Kettering Cancer Center and targets the WT1 protein, which is present in an array of tumor types. GPS has potential as a monotherapy or in combination with other therapies to address a broad spectrum of hematologic malignancies and solid tumor indications. The Company is also developing GFH009, a small molecule, highly selective CDK9 inhibitor, which is licensed from GenFleet Therapeutics (Shanghai), Inc., for all therapeutic and diagnostic uses in the world outside of Greater China. For more information on SELLAS, please visit www.sellaslifesciences.com.

Salarius Pharmaceuticals, Inc. (Nasdaq: SLRX), a clinical-stage biopharmaceutical company developing potential new medicines for patients with sarcomas, pediatric cancers, today announced an important dosing milestone in the Phase 1/2 Sarcoma clinical trial evaluating seclidemstat as a treatment for Ewing sarcoma and other FET-rearranged sarcomas. The trial’s Ewing sarcoma patient arm investigating seclidemstat in combination with chemotherapy agents topotecan and cyclophosphamide (TC) has advanced to the second lead-in safety cohort treating patients with seclidemstat at 900 mg BID in combination with topotecan and cyclophosphamide. Salarius continues to enroll patients with FET-rearranged sarcomas in a separate trial arm investigating single-agent seclidemstat administered at a 900 mg BID dose. Seclidemstat is a novel, oral, reversible inhibitor of the lysine-specific histone demethylase 1 enzyme (LSD1), an enzyme that has been shown to play a key role in the development and progression of certain cancers. “Advancing to the 900 mg safety lead-in cohort in the Ewing sarcoma trial arm marks the latest milestone in what has been a productive year for our clinical programs investigating seclidemstat,” stated David Arthur, CEO of Salarius Pharmaceuticals. “During the past several months, we have almost doubled the number of active trial sites participating in the Sarcoma clinical trial. Meanwhile, enrollment continues across all patient groups, and we continue to anticipate potential data readouts in 2022.” The Phase 1/2 Sarcoma trial is an open label study exploring the safety and efficacy of seclidemstat in three patient groups. Patients with Ewing sarcoma, a deadly pediatric bone cancer, are receiving seclidemstat in combination with topotecan and cyclophosphamide as a second- and third-line treatment. The other patient arms are investigating seclidemstat as a single-agent therapy in patients with myxoid liposarcoma and other FET-rearranged sarcomas. Patient recruitment for the Sarcoma trial is now occurring at 13 clinical trial sites across the U.S. These sites include Children’s Hospital of Los Angeles (Los Angeles, CA); Cleveland Clinic (Cleveland OH), Fox Chase Cancer Center (Philadelphia, PA), Dana-Farber Cancer Institute (Boston, MA); Johns Hopkins All Children’s Hospital (St. Petersburg, FL); MD Anderson Cancer Center (Houston, TX); Memorial Sloan Kettering Cancer Center (New York, NY); Moffitt Cancer Center (Tampa, FL); Nationwide Children’s Hospital (Columbus, OH); Oncology Consultants (Houston, TX); Sarcoma Oncology Center (Santa Monica, CA); Virginia Cancer Specialists (Fairfax, VA) and Washington University (St. Louis, MO). About Salarius Pharmaceuticals Salarius Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company developing cancer therapies for patients in need of new treatment options. Salarius’ lead candidate, seclidemstat, is being studied as a potential treatment for pediatric cancers, sarcomas, and other cancers with limited treatment options. Seclidemstat is currently in a Phase 1/2 clinical trial for relapsed/refractory Ewing sarcoma and select, additional sarcomas that share a similar biology to Ewing sarcoma, also referred to as Ewing-related or FET-rearranged sarcomas. Seclidemstat has received Fast Track Designation, Orphan Drug Designation, and Rare Pediatric Disease Designation for Ewing sarcoma from the U.S. Food and Drug Administration. Salarius is also exploring seclidemstat’s potential in several cancers with high unmet medical need, with a second Phase 1/2 clinical study initiated by MD Anderson Cancer Center in hematologic cancers. Salarius has received financial support from the National Pediatric Cancer Foundation to advance the Ewing sarcoma clinical program and was also a recipient of a Product Development Award from the Cancer Prevention and Research Institute of Texas (CPRIT).